Diazoline (Diazolin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceMebrogrolineMebrogroline
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    VALENTA PHARM, PAO     Russia
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    VALENTA PHARM, PAO     Russia
  • Diazoline
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    VALENTA PHARM, PAO     Russia
    • Dosage form: & nbsppills.
    Composition:Dragee contains diazolin 0,05 g or 0,1 g and auxiliary substances (sugar, starch syrup, polyvinylpyrrolidone low molecular weight or polyvinylpyrrolidone medium molecular weight, sunflower oil, beeswax, talc).
    Description:The dragee is white or white with a yellowish tint of color. Inside the dragee is white or white with a slightly creamy or slightly greenish tinge.
    Pharmacotherapeutic group:H1-histamine receptor antagonist.
    ATX: & nbsp

    R.06.A.X.15   Mebrogroline

    R.06.A.X   Other antihistamines for systemic use

    Pharmacodynamics:The H1 blocker is the histamine receptor. Has anti-allergic effect, reduces swelling of mucous membranes.Weakens the action of histamine on the smooth muscles of the bronchi, uterus and intestines, reduces the severity of lowering blood pressure and increasing the permeability of blood vessels. Slightly penetrating the central nervous system, in contrast to antihistamines of the first generation, does not have a pronounced sedative and hypnotic effect. Has mildly expressed M-cholinergic and anesthetic properties. The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days.
    Pharmacokinetics:Quickly absorbed from the gastrointestinal tract, can cause irritation of the mucous membrane of the stomach, penetrates into all tissues of the body. Bioavailability varies between 40-60%. The half-life of the plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier. Metabolised in the liver by methylation, induces microsomal enzymes of the liver, excreted by the kidneys.
    Indications:Prophylaxis and treatment of seasonal and allergic rhinitis, hay fever, urticaria, Quincke edema, allergic dermatoses accompanied by pruritus (eczema, neurodermatitis, etc.),allergic conjunctivitis, skin reaction after an insect bite.
    Contraindications:Hypersensitivity, prostatic hyperplasia, angle-closure glaucoma, gastric ulcer and duodenal ulcer disease, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac arrhythmias (having vagolytic effect, can improve the atrioventricular conduction and promote supraventricular arrhythmias).

    Carefully:Use with caution in patients with hepatic and renal insufficiency (dose adjustment and intervals between doses may be required).
    Pregnancy and lactation:It is not recommended to take the drug during pregnancy. During breastfeeding should stop taking the drug.
    Dosing and Administration:

    Dragee should be taken orally, without chewing, during or immediately after eating. Adults and children from 12 years of age are prescribed 0.1 g 1-3 times a day, children over 2 years old - 0.05 g 1-2 times a day, from 5 years - 0.05 g 2-3 times per day day, children 5-10 years - 0.05 g 2-4 times a day. Higher doses for adults: single - 0.3 g, daily - 0.6 g. The duration of the course of treatment is determined by the nature of the disease and the therapeutic effect achieved.

    Side effects:From the gastrointestinal tract: has an irritant effect on the mucous membrane of the gastrointestinal tract, manifested dyspeptic phenomena (heartburn, nausea, pain in the epigastric region, etc.).
    From the nervous system: dizziness, paresthesia, tremor, fatigue, drowsiness, anxiety (at night), slowing the reaction rate.
    Other: dry mouth, delay urination, allergic reactions, extremely rarely - granulocytopenia and agranulocytosis.
    Children - paradoxical reactions: increased excitability, irritability, tremor, sleep disturbance.

    Interaction:Strengthens the action of ethanol, sedatives.
    Special instructions:It is not effective for bronchial asthma and anaphylactic shock.
    Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.
    Form release / dosage:Dragee to 0.05 grams and 0.1 grams in a contiguous cell pack of 10 pieces. For 2, 3, 4 or 5 contour packs, together with the instructions for use are placed in a pack of cardboard.It is allowed to put 100 contour mesh packages in a cardboard box or in polyethylene film bags with application instructions equal to the number of packages.
    Storage conditions:In dry place inaccessible to children at a temperature not exceeding 25 ° C.
    Shelf life:3 years 6 months.
    Do not use after the expiration date indicated on the package.
    Terms of leave from pharmacies:Without recipe
    Registration number:P N002412 / 01-2003
    Date of registration:01.07.2008
    The owner of the registration certificate:VALENTA PHARM, PAO VALENTA PHARM, PAO Russia
    Manufacturer: & nbsp
    Information update date: & nbsp01.07.2008
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