Active substanceMebrogrolineMebrogroline Similar drugsTo uncover Diazoline pills inwards FARMAK, PAO Ukraine Diazoline pills inwards AVVA RUS, OJSC Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Diazoline pills inwards FARMSTANDART-UFAVITA, JSC Russia Diazoline pills inwards MIR-FARM, LLC Russia Diazoline pills inwards FARMAK, PAO Ukraine Diazoline pills inwards MARBIOFARM, OJSC Russia Diazoline pills inwards OZONE, LLC Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Dosage form: & nbsppills Composition:1 tablet contains mebhydroline in terms of 100% of the substance 100 mg; Excipients:lactose monohydrate (200) - 30 mg, potato starch, -104.4 mg, povidone -1.35 mg, sucrose 33 mg, calcium stearate -1.25 mg. Description:Round flat cylindrical tablets. white or almost white with a risk and a bevel. Pharmacotherapeutic group:antiallergic agent - Hi-histamine, receptor blocker. ATX: & nbspR.06.A.X.15 MebrogrolineR.06.A.X Other antihistamines for systemic use Pharmacodynamics:Mebrogroline refers to antihistamines, is a blocker of Hi-receptors of histamine. Mebrogroline reduces the effect of histamine in the smooth muscles of the bronchi, intestines and uterus, as well as its effect on vascular permeability.Unlike antihistamines of the first generation (diphenhydramine, Clemastine). has a less pronounced sedative and hypnotic effect. Has mildly expressed m-holinoblokiruyuschimi and anesthetic properties. The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 48 hours. Pharmacokinetics:Quickly absorbed from the digestive tract. Bioavailability varies within 1 / 40-60%. The drug practically does not penetrate the blood-brain barrier, is metabolized in the liver by methylation, induces enzymes of the liver, is excreted from the body by the kidneys. Indications:Allergic rhinitis, hay fever, hives, food and drug allergies, skin reactions after insect bites, allergic dermatoses, accompanied by pruritus (eczema, neurodermatitis). Contraindications:Hypersensitivity to the components of the drug. Peptic ulcer of the stomach and duodenum, inflammatory diseases of the gastrointestinal tract, pyloric stenosis. Closed-angle glaucoma. Hyperplasia of the prostate. Epilepsy.Heart rhythm disturbances (having a vagolytic effect, can improve AV conduction and promote the development of supraventricular arrhythmias). Children under 3 years. Pregnancy. Lactation period. Deficiency of sugarase / isomaltase, fructose intolerance, glucose-galactose malabsorption, lactase deficiency, lactose intolerance (because the preparation contains sucrose and lactose). Carefully:Hepatic and / or renal failure (dose adjustment and interval between doses may be required). Pregnancy and lactation:It is not recommended to use during pregnancy and lactation. Dosing and Administration:Take inside during or immediately after a meal. Adults and children from 12 years of age are prescribed 100-200 mg (1-2 tablets) 1-3 times a day, children 3-5 years - 50 mg (1/2 tablets) 1-2 times a day, children 5 -12 years - 50 mg (1/2 tablet) 2-3 times a day. Maximum doses for adults: single dose - 300 mg, daily - 600 mg. The maximum daily dose for children 3-5 years is 100 mg; children 5-12 years - 150 mg. The duration of treatment is determined by the nature of the disease and the therapeutic effect achieved. Side effects:On the part of the digestive system: an irritant effect on the mucous membrane of the gastrointestinal tract, manifested dyspepsia (heartburn, nausea, pain in the epigastric region). From the side of the central nervous system: dizziness, paresthesia, increased fatigue, drowsiness, blurred vision, slowing the speed of the psychomotor reaction. Others: dry mouth, urinary retention, allergic reactions, granulocytopenia and agranulocytosis. Children - paradoxical reactions: increased excitability, tremor, sleep disturbances. Overdose:Symptoms: confusion, drowsiness, impaired coordination of motion, suppression of central nervous system (up to coma) or stimulating effect on the central nervous system (more often in children); manifestations of anticholinergic action: dryness of the oral mucosa, dilated pupils, "tides" of blood to the upper half of the trunk, nausea, vomiting, epigastric pain.Treatment: drug withdrawal, gastric lavage, activated charcoal, symptomatic therapy. Allergic reactions are dose-independent. Interaction:Diazolin enhances the effect of hypnotics, sedatives and other drugs that depress the central nervous system, as well as alcohol. Effect on the ability to drive transp. cf. and fur:During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased attention and speed of psychomotor reactions. Form release / dosage:Tablets of 100 mg. Packaging:For 10 tablets in a blister of a film of PVC colorless or light-shielding colored and aluminum foil printed lacquered. For 1 or 2 blisters together with instructions for medical use put in a pack of cardboard. Storage conditions:In the dark place at a temperature of no higher than 25 ° C /.Keep out of the reach of children. Shelf life:2 years. Do not use after the expiration date printed on the package. Terms of leave from pharmacies:Without recipe Registration number:П N010988 / 01 Date of registration:20.09.2011 The owner of the registration certificate:FARMAK, PAO FARMAK, PAO Ukraine Manufacturer: & nbspFARMAK, PAO Ukraine Representation: & nbspFARMAK PAOFARMAK PAO Information update date: & nbsp20.09.2011 Illustrated instructions × Illustrated instructions Instructions