Diazolin - instructions for use, doses, side effects, contraindications

Composition:Composition for one pills:
active substance: mebhydroline - (mebhydroline napadisylate) -100 mg;
Excipients: sucrose (sugar) - 227.617 mg, starch syrup - 21.505 mg, sunflower oil - 0.068 mg, beeswax - 0.068 mg, talc - 0.342 mg, polysorbate 80 (tween 80) - 0.400 mg.

Description:The dragee is white or white with a yellowish hue of color, a spherical shape. On a cross-section of a dragee of white or white with slightly kremovatym or slightly greenish shade of color. The surface of the dragee should be smooth, smooth, uniform in color.

Pharmacotherapeutic group:antiallergic agent - Hi-histamine, receptor blocker.

ATX: & nbsp

R.06.A.X.15 Mebrogroline

R.06.A.X Other antihistamines for systemic use

Pharmacodynamics:The blocker of Hi-antihistamine receptors.It reduces the antiallergic effect, reduces the swelling of the mucous membranes. Weaken the effect of histamine on the smooth muscles of the bronchi, uterus, intestines, reduces the severity of lowering blood pressure and increasing the permeability of blood vessels. Slightly penetrating the central nervous system, in contrast to antihistamines of the first generation, does not have a pronounced sedative and hypnotic effect. Has weakly expressed M-cholinergic and anesthetic properties. The therapeutic effect develops 15-30 minutes after administration, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days.

Pharmacokinetics:quickly absorbed from the gastrointestinal tract, can cause irritation of the gastric mucosa, penetrates into all tissues of the body. Bioavailability varies between 40-60%. The half-life from the plasma is about 4 hours. The drug practically does not penetrate the blood-brain barrier. Metabolised in the liver by methylation, induces microsomal enzymes of the liver, excreted by the kidneys.

Indications:Prevention and treatment of seasonal and allergic rhinitis, hay fever, hives, Quincke edema,allergic dermatoses accompanied by skin itching (eczema, neurodermatitis, etc.), allergic conjunctivitis, skin reaction after an insect bite.

Contraindications:Increased sensitivity, prostatic hyperplasia, zakratougolnaya form of glaucoma, peptic ulcer of the stomach and duodenum, other inflammatory diseases of the gastrointestinal tract, pyloric stenosis, epilepsy, cardiac rhythm disturbances (having a vagolytic effect, can improve atrioventricular conduction and promote the development of supraventricular arrhythmias), children's age up to 12 years (for this dosage form).

Carefully:Use with caution in patients with hepatic and renal insufficiency (dose adjustment and intervals between doses may be required).

Pregnancy and lactation:

It is not recommended to use the drug during pregnancy. During breastfeeding should stop taking the drug.

Dosing and Administration:Dragee should be taken orally, without chewing, during or immediately after eating. Adults and children from 12 years of age are prescribed 100 mg 1-3 times a day. Higher doses for adults: single dose - 300 mg, daily - 600 mg.The duration of the course of treatment is determined by the nature of the disease and the therapeutic effect achieved.

Side effects:From the gastrointestinal tract: has an irritant effect on the mucous membrane of the gastrointestinal tract, manifested dyspeptic phenomena (heartburn, nausea, pain in the epigastric region, etc.).
From the nervous system: dizziness, paresthesia, tremor, fatigue, drowsiness, anxiety (at night), slowing the reaction rate.
Other: dry mouth, delay urination, allergic reactions, extremely rarely - granulocytopenia and agranulocytosis.
Children - paradoxical reactions: increased excitability, irritability, tremor, sleep disturbances.

Interaction:

Strengthens the action of ethanol, sedatives.

Special instructions:It is not effective for bronchial asthma and anaphylactic shock.
In children from 2 to 12 years of age, it is recommended to use 0.05 mg tablets.

Effect on the ability to drive transp. cf. and fur:During the treatment period it is necessary to refrain from driving motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:Dragee for 100 mg. 10 pieces per contour mesh package made of polyvinylchloride film and aluminum foil or 20 pieces in orange glass cans with screwed plastic covers or in polymer jars. 1, 2, 3 or 5 contour mesh packages or a jar along with instructions for use are placed in a pack of cardboard for consumer containers. 150 contour mesh packages, together with an equal number of instructions for use, are placed in a bag of polyethylene film opaque.
Each package is packed in a carton box box (group packaging).

Packaging:

cans of orange glass (1) -tacks of cardboard (20)
cans, polymeric (1) -tacks, cardboard (20)
packings, cellular, planimetric (1) -tacks, cardboard (10)
packings cellular outline (150) -packages polyethylene light-proof-boxes cardboard
packings, cellular, planimetric (2), cardboard
packings, cellular, planimetric (3), cardboard
packings, cellular, planimetric (5), cardboard

Storage conditions:In a dry, protected from light place at a temperature of no higher than 25 ° C.
Keep out of the reach of children.

Shelf life:3 years 6 months
Do not use after the expiration date indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:LSR-005032/08

Date of registration:30.06.2008

The owner of the registration certificate:MARBIOFARM, OJSC MARBIOFARM, OJSC Russia

Manufacturer: & nbsp

MARBIOFARM, OJSC Russia

Information update date: & nbsp19.07.2013

Illustrated instructions

Instructions

Diazoline (Diazolin)