Active substanceMebrogrolineMebrogroline Similar drugsTo uncover Diazoline pills inwards FARMAK, PAO Ukraine Diazoline pills inwards AVVA RUS, OJSC Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Diazoline pills inwards FARMSTANDART-UFAVITA, JSC Russia Diazoline pills inwards MIR-FARM, LLC Russia Diazoline pills inwards FARMAK, PAO Ukraine Diazoline pills inwards MARBIOFARM, OJSC Russia Diazoline pills inwards OZONE, LLC Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Diazoline pills inwards VALENTA PHARM, PAO Russia Dosage form: & nbsppills Composition:Dragee contains diazoline 50 mg or 100 mg;Excipients: sugar 0,187 g or 0,23 g, starch treacle 0,01265 g or 0,0193 g, sunflower oil 0,00005 g or 0,0002 g, beeswax 0,00005 g or 0,0002 g, talc 0,00025 g or 0.0003 g. Description:The dragee is white in color, spherical in shape, two layers are visible on the cross section: the inner layer is white or white with a creamy or slightly greenish hue, the color and the outer layer of white color. The surface of the dragee should be smooth, smooth and uniform in color. Pharmacotherapeutic group:Antiallergic agent - H1-histamine, receptor blocker. ATX: & nbspR.06.A.X.15 MebrogrolineR.06.A.X Other antihistamines for systemic use Pharmacodynamics:Mebrogroline - blocker of histamine Hi-receptors, reduces the spasmogenic effect of histamine against smooth muscles of the bronchi, intestines, uterus, as well as its effect on vascular permeability. Unlike antihistamines of the first generation (diphenhydramine, Clemastine ) has a less pronounced sedative and hypnotic effect. Has mildly expressed m-holinoblokiruyuschimi and anesthetic properties. The therapeutic effect develops 15-30 minutes after taking, the maximum effect is observed after 1-2 hours. The duration of the effect can reach 2 days. Pharmacokinetics:Quickly absorbed from the digestive tract. Bioavailability varies between 40-60%. The drug practically does not penetrate the blood-brain barrier, is metabolized in the liver by methylation, induces enzymes of the liver, is excreted from the body by the kidneys. Indications:Allergic rhinitis, hay fever, hives, food and drug allergies, skin reactions after insect bites, allergic dermatoses, accompanied by pruritus (eczema, neurodermatitis). Contraindications:Hypersensitivity to the components of the drug.Peptic ulcer - stomach and duodenal ulcers, inflammatory diseases of the gastrointestinal tract, pyloric stenosis. Closed-angle glaucoma. Hyperplasia of the prostate, gland. Epilepsy. Heart rhythm disturbances (having a vagolytic effect, can improve AV conduction and - promote development, supraventricular arrhythmias). Deficiency of sucrose / isomaltose, intolerance to fructose, glucose-galactose - malabsorption. Children under 3 years. Pregnancy. Lactation period. Carefully:Hepatic and / or renal failure (dose adjustment and interval between doses may be required). Pregnancy and lactation:It is not recommended to use during pregnancy and lactation. Dosing and Administration:Take inside without chewing, during or immediately after eating. Adults and children from 12 years of age are prescribed 0.01-0.02 g 1-3 times a day, children from 3 to 5 years - 0.05 g 1-2 times a day, from 5 to 10 years - to 0 , 05 g 2-3 times a day, from 10 to 12 years - 0.05 g 2-4 times a day. Maximum doses for adults: single-dose 0.3 g, daily - 0.6 g. The duration of treatment is determined by the nature of the disease and the therapeutic effect achieved. Side effects:From the digestive system: Diazoline can irritate the mucous membranes of the gastrointestinal tract, which is sometimes manifested by dyspepsia (heartburn, nausea, pain in the epigastric region).From the central nervous system: dizziness, paresthesia, increased fatigue, drowsiness, blurred vision, slowed speed, psychomotor reaction.Others: dry mouth, urinary disorders, urinary retention, allergic reactions. Possible occurrence of granulocytopenia and agranulocytosis.Paradoxical reactions are sometimes observed in children: increased excitability, tremor, sleep disturbances. Overdose:Symptoms: confusion, drowsiness, impaired coordination of motion, depression, central nervous system functions (up to coma) or stimulating effect on the central nervous system (more often in children); manifestations of anticholinergic action: dryness of the oral mucosa, dilated pupils, "hot flashes" of blood to the upper half of the trunk, nausea, vomiting, epigastric pain. Allergic reactions are dose-independent. Treatment: cancellation of the drug, gastric lavage, the reception of activated charcoal, symptomatic therapy. Interaction:Diazolin enhances the effect of hypnotics, sedatives and other drugs that depress the central nervous system, as well as alcohol. Effect on the ability to drive transp. cf. and fur:During the treatment period, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions. Form release / dosage:Dragee by 50 mg or 100 mg. Packaging:For 10 dragees in a blister of a film of PVC colorless or light-protective and aluminum foil printed lacquered. For 1 or 2 blisters together with instructions for medical use put in a pack of cardboard. Storage conditions:In the dark place at a temperature of no higher than 25 ° C.Keep out of the reach of children. Shelf life:3 years 6 months.Do not use after the expiration date printed on the package. Terms of leave from pharmacies:On prescription Registration number:П N015876 / 01 Date of registration:23.10.2009 The owner of the registration certificate:FARMAK, PAO FARMAK, PAO Ukraine Manufacturer: & nbspFARMAK, PAO Ukraine Representation: & nbspFARMAK PAOFARMAK PAO Information update date: & nbsp10/23/2009 Illustrated instructions × Illustrated instructions Instructions