Erythromycin (Erythromycin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceErythromycinErythromycin
Dosage form: & nbspointment eye
Composition:

1 g of ointment contains:

active substance: erythromycin with an activity of 10,000 units, calculated on an anhydrous substance, 0.01 g;

Excipients: lanolin anhydrous 0.4 g, sodium disulfite 0.0001 g, vaseline up to 1.0 g.

Description:

Ointment from yellowish to brownish-yellow color.

Pharmacotherapeutic group:antibiotic-macrolide
ATX: & nbsp

S.01.A.A.17   Erythromycin

J.01.F.A.01   Erythromycin

Pharmacodynamics:

Bacteriostatic antibiotic from the group of macrolides. With topical application has antibacterial effect. Reversibly binds to 50S subunit of ribosomes, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of proteins of microorganisms (does not affect the synthesis of nucleic acids). When used in high doses depending on the type of pathogen can exhibit bactericidal action. Effective against sensitive microorganisms that cause superficial eye infections of the corneal conjunctiva, incl. in a relationship Neisseria gonorrhoeae, Chlamydia trachomatis.

Pharmacokinetics:

Absorbed in the cornea and watery eyes. With local application is achieved

the therapeutic concentration of erythromycin in the tissues of the eye, systemic absorption is low. If the corneal epithelium is damaged, the effective concentration of erythromycin in the moisture of the anterior chamber is reached 30 minutes after the application.
Indications:

Eye infections caused by sensitive microorganisms: conjunctivitis, (including newborns), bacterial blepharitis, blepharoconjunctivitis, meibomitis; in the complex therapy of bacterial keratitis, chlamydial conjunctivitis, blepharo-conjunctivitis, trachoma; prevention of neonatal blennery.

Contraindications:Hypersensitivity to the components of the drug, severe violations of the liver and kidneys, jaundice in the history.
Carefully:

Apply with caution to patients with impaired liver and kidney function.

Pregnancy and lactation:Sufficient experience in the use of the drug during pregnancy and lactation is not present. It is possible to use erythromycin to treat pregnant women as prescribed by the doctor if the expected therapeutic effect exceeds the risk of possible side effects.During the prescription of the drug, breastfeeding should be discontinued.
Dosing and Administration:

Locally.

A strip of ointment 0.5-1 cm long is placed in the lower or upper eyelid 3 times a day, and when treating trachoma 4-5 times a day.
The duration of treatment depends on the form and severity of the disease, but should not exceed 14 days.
When trachoma treatment should be combined with the expression of follicles.
When the inflammatory process stops, the drug is used 2-3 times a day.
The duration of treatment for trachoma should not exceed 4 months.
Side effects:Local reactions: hyperemia, irritation of the mucous membrane of the eye, blurred vision, allergic reactions.
Overdose:Data on drug overdose are absent.
Interaction:

Incompatible with lincomycin, clindamycin and chloramphenicol (antagonism).

Reduces the bactericidal action of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

Pharmaceutically incompatible with aminoglycosides.

When used with corticosteroids leads to an increase in their effect.

Special instructions:

When ophthalmia of newborns is prevented, the ophthalmic ointment of erythromycin should not be washed out of the eye.

In children whose mothers have clinically pronounced gonorrhea, erythromycin as an ophthalmic drug is used concomitantly with an aqueous solution of penicillin G for parenteral use.

Effect on the ability to drive transp. cf. and fur:

Patients who temporarily lose visual clarity after application are not advised to drive a car or work with complicated equipment, machines or any other complicated equipment requiring clear vision immediately after application of the drug.

Form release / dosage:

Ointment eye, 10000 U / g.

Packaging:

By 3 g or 10 g in tubes of aluminum.

Tubu together with instructions for use are placed in a cardboard pack.

Storage conditions:

In the dark place at a temperature of no higher than 15 ° C.

Keep out of the reach of children.

Shelf life:

3 years.

Do not use the drug after the expiry date.

Terms of leave from pharmacies:On prescription
Registration number:LS-002421
Date of registration:01.08.2011
The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia
Manufacturer: & nbsp
Representation: & nbspTATHIMFARM PREPARATIONS OJSC TATHIMFARM PREPARATIONS OJSC Russia
Information update date: & nbsp29.09.2015
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