Erythromycin - instructions for use, dose, side effects, contraindications

Erythromycin is an antibiotic from the macrolide group. In therapeutic doses has a bacteriostatic effect. Erythromycin reversibly binds to the ribosomes of bacteria, thereby suppressing protein synthesis.

The spectrum of action includes Gram-positive (Staphylococcus spp., producing and non-producing penicillinase; Streptococcus spp., incl. S.pneumoniae, Clostridium spp., Bacillus anthracis, Corynebacterium diphtheriae) and some gram-negative bacteria ( Neisseria gonorrhoeae, Haemophillus influenzae, Bordetella pertussis, Brucella spp., Legionella spp.), Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp.. Gram-negative rods are resistant to erythromycin, incl. Esherichia coli, Pseudomonas aeruginosa, and Shigella spp., Salmonella spp..

Pharmacokinetics:The drug is well absorbed from the gastrointestinal tract. Active penetrates into tissues, fluids and body cavities, does not penetrate the blood-brain barrier. Metabolized in the liver, excreted with bile. Unchanged in the urine is allocated less than 5%. The drug does not possess cumulative properties.

Indications:

Erythromycin is used for pneumonia, bronchiectasis in the stage of exacerbation and other infectious diseases caused by microorganisms susceptible to antibiotics, septic conditions, erysipelas, mastitis, osteomyelitis, peritonitis, purulent otitis and other purulent inflammatory processes. Assign also with syphilis in case of intolerance to antibiotics of the penicillin group.

Contraindications:

The use of erythromycin is contraindicated in cases of hypersensitivity to macrolides, severe impairment of liver function. Anamnestic information on jaundice.

Carefully:

The drug is administered with caution in case of violations of the liver and / or kidney function.

Pregnancy and lactation:Erythromycin penetrates through the placenta, excreted in breast milk, so when prescribing the drug during pregnancy and lactation it is necessary to evaluate the estimated benefit to the mother and the potential risk to the fetus.

Dosing and Administration:

Erythromycin is administered orally. Single dose for adult is 0.25 g, when severe diseases - Take 0.5 g every 4-6 hours for 1-1.5 hours before eating or 2-3 hours after a meal. The highest single dose for adults: 0.5 g, daily 4 g.

Babies drug administered in a daily dose of 30-50mg per kg body weight, depending on the characteristics of the disease and age of the patient every 6 hours (4 times a day); 8 hours (3 times a day); 12 hours (2 times a day):

Body mass	Daily dose
Less than 10 kg	30-50 mg / kg (15-25 mg / kg twice)
10-15 kg	200 mg (1 tablet of 100 mg twice)
16-25 kg	400 mg (1 tablet of 100 mg four times)
26-50 kg	800 mg
51-100 kg	1200 mg
More than 100 kg	1600 mg

The duration of treatment depends on the form and severity of the disease and is 5-14 days.

Side effects:

Adverse events are relatively rare (nausea, vomiting, diarrhea, cholestatic jaundice).In some cases, with increased sensitivity to the drug allergic reactions occur (rash, hives, anaphylactic shock).

With prolonged use, there may be violations of the liver function, candidiasis of the oral cavity.

Interaction:

Drugs that increase the acidity of gastric juice and acidic foods inactivate erythromycin.

Erythromycin increases the concentration in the blood plasma of theophylline, caffeine, carbamazepine, enhancing their toxic effect (nausea, vomiting, etc.).

Erythromycin increases the concentration of cyclosporine in the blood plasma and may increase the risk of developing nephrotoxic reactions.

The action of erythromycin is enhanced in combination with sulfonamides, tetracyclines, streptomycin.

Special instructions:

When treating erythromycin, it is necessary to take into account the rapid development of antibiotic resistance of microorganisms, which also has a cross-over character with respect to other antibiotics - macrolides (oleandomycin).

Erythromycin can be prescribed for allergies to penicillins.

Erythromycin can not be washed down with milk and dairy products.

Form release / dosage:The tablets, covered with an enteric aqueous coating, 100 mg and 250 mg.

Packaging:

For 10 or 20 pieces in glass bottles or in contour cell packs.

Storage conditions:

In a dry place at room temperature (15-25 FROM ).

Keep out of the reach of children.

Shelf life:

2 years.

Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:P N000139 / 01

Date of registration:05.12.2007

The owner of the registration certificate:SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products Russia

Manufacturer: & nbsp

SYNTHESIS, OJSC Russia

Representation: & nbspSYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products SYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products Russia

Information update date: & nbsp30.09.2015

Illustrated instructions

Instructions

Erythromycin (Erythromycin)