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Single dose for adults and adolescents, over 14 years, is 0.25-0.5 g, daily - 1-2 g. The interval between the appointment is 6 hours. In severe infections, the daily dose can be increased to 4 g.
For the treatment of diphtheria carriage - 0.25 g 2 times a day. The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days.
With amoebic dysentery, 0.25 g four times a day; the duration of the course is 10-14 days.
In legionellosis, 0.5-1 g four times a day for 14 days.
With gonorrhea - 0.5 g every 6 hours for 3 days, then 0.25 g every 6 hours for 7 days.
For preoperative preparation of the intestine in order to prevent infectious complications - inside, 1 g for 19 hours, 18 hours and 9 hours before the start of surgery (only 3 g).
For the prevention of streptococcal infection (with tonsillitis, pharyngitis) - 20-50 mg / kg / day; the duration of the course is not less than 10 days.
For the prevention of septic endocarditis in patients with heart defects - 1 g for 1 h before the therapeutic or diagnostic procedure, then 0.5 g again at 6 h.
With pertussis - 40-50 mg / kg / day for 5-14 days.
When urogenital infections during pregnancy - 0.5 g 4 times a day for at least 7 days or (if the tolerance is poor) - 0.25 g 4 times a day for at least 14 days.
In uncomplicated chlamydia and intolerance tetracyclines - 0.5 g 4 times a day for at least 7 days.