Erythromycin (Erythromycin)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceErythromycinErythromycin
Dosage form: & nbspointment eye
Composition:

In 1 g of ointment contains:

active substance: erythromycin 10 thousand units;

Excipients: lanolin (lanolin anhydrous) 0.4 g, sodium disulfite (sodium metasulfite, sodium pyrosulfite) 0.0001 g, petroleum jelly "for eye ointments" up to 1 g.

Description:Ointment from light yellow to brownish-yellow color.
Pharmacotherapeutic group:antibiotic-macrolide
ATX: & nbsp

S.01.A.A.17   Erythromycin

J.01.F.A.01   Erythromycin

Pharmacodynamics:Erythromycin is an antibiotic from the macrolide group that is produced Streptomyces erythreus.
With topical application has antibacterial effect. Reversibly binds to 50S subunit of ribosomes, which disrupts the formation of peptide bonds between amino acid molecules and blocks the synthesis of proteins of microorganisms (does not affect the synthesis of nucleic acids). When used in high doses depending on the type of pathogen can exhibit bactericidal action.
Effective against sensitive microorganisms that cause superficial eye infections of the conjunctiva, cornea, incl.in a relationship Neisseria gonorrhoeae, Chlamydia trachomatis.
Pharmacokinetics:

Absorbed in the cornea and watery eyes. With topical application, systemic absorption is low. Bioavailability is 30-65%. It is distributed in most tissues and body fluids. Binding to plasma proteins is 70-90%. Metabolised in the liver, partly with the formation of inactive metabolites. The half-life is 1.4-2 hours. It is excreted by the intestines and kidneys.

Indications:

Eye infections caused by sensitive microorganisms: conjunctivitis (including in newborns), bacterial blepharitis, blefaroconjunctivitis, meibomitis; in complex therapy, bacterial keratitis, chlamydial conjunctivitis, blepharoconjunctivitis, trachoma; prevention of neonatal blennery.

Contraindications:

Individual hypersensitivity to the components of the drug, severe dysfunction of the liver and kidneys, jaundice in the anamnesis.

Carefully:

Elderly age, impaired renal and hepatic function.

Pregnancy and lactation:

Application in pregnancy is possible only in case of emergency, when the probable benefit to the mother exceeds the risk to the fetus.

If it is necessary to prescribe the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

Ointment is placed behind the lower eyelid in the form of a strip 1-1.3 cm long 3 times a day.

Duration of treatment of neonatal ophthalmia, bacterial conjunctivitis, blepharitis, blepharoconjunctivitis, meibomite, with complex therapy of keratitis depends on the form and severity of the disease, but should not exceed 14 days.

When treating trachoma - 4-5 times a day, treatment should be combined with dissection of follicles; when the inflammatory process stops, the drug is used 2-3 times a day. Duration of treatment of trachoma up to 4 months.

In the treatment of chlamydial conjunctivitis ointment is placed in the conjunctival sac 4-5 times a day, the duration of treatment depends on the severity of the disease, up to 3 months.

For the prevention of blenearitis in newborns, a strip of ointment with a length of 0; 5-1 cm is inserted in the lower eyelid once.

Side effects:

Local reactions: hyperemia, irritation of the mucous membrane of the eye, blurred vision, allergic reactions.

Overdose:

Data on drug overdose are absent.

Interaction:

The drug is incompatible with lincomycin, clindamycin, chloramphenicol (antagonism).

Reduces the bactericidal action of beta-lactam antibiotics (penicillins, cephalosporins, carbopenems).

Pharmaceutically incompatible with aminoglycosides.

When used with corticosteroids leads to an increase in their effect.

Special instructions:

When ophthalmia of newborns is prevented, the ophthalmic ointment of erythromycin should not be washed out of the eye.

In children whose mothers have clinically pronounced gonorrhea, erythromycin as an ophthalmic drug is used concomitantly with an aqueous solution of penicillin G for parenteral administration.

After opening the tube use within 1 month.

Effect on the ability to drive transp. cf. and fur:During treatment, one should refrain from driving vehicles and servicing machines and mechanisms that require clarity of vision immediately after application.
Form release / dosage:

Ointment eye, 10 thousand units / g.

Packaging:

3 g, 5 g, 10 g in tubes of aluminum or laminate.

Each tube with instruction for use is placed in a pack of cardboard.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use the product after the expiry date printed on the package.

Terms of leave from pharmacies:On prescription
Registration number:P N002127 / 01
Date of registration:06.11.2008
The owner of the registration certificate:SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products SYNTHESIS, JSC Joint-stock Kurgan Society of Medical Preparations and Products Russia
Manufacturer: & nbsp
Representation: & nbspSYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products SYNTHESIS JSC Joint-Stock Kurgan Society of Medical Preparations and Products Russia
Information update date: & nbsp30.09.2015
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