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A single dose for adults and adolescents over the age of 14 is 0.25-0.5 g, daily - 1-2 g. The interval between prescribing is 6 hours. In severe infections, the daily dose can be increased to 4 g.
Children from 4 months to 18 years, depending on the age, body weight and severity of infection - 30-50 mg / kg / day in 2-4 admission; children of the first 3 months of life - 20-40 mg / kg / day. In case of more severe infections, the dose can be doubled.
For the treatment of diphtheria carriage - 0.25 g 2 times a day. The course dose for the treatment of primary syphilis is 30-40 g, the duration of treatment is 10-15 days.
With amoebic dysentery adults - 0.25 grams 4 times a day, children - 30-50 mg / kg / day; the duration of the course is 10-14 days.
In legionellosis, 0.5-1 g four times a day for 14 days.
With gonorrhea - 0.5 g every 6 hours for 3 days, then 0.25 g every 6 hours for 7 days.
For preoperative preparation of the intestine in order to prevent infectious complications - inside, 1 g for 19 hours, 18 hours and 9 hours before the start of surgery (only 3 g).
To prevent streptococcal infection (with tonsillitis, pharyngitis), adults - 20-50 mg / kg / day, children - 20-30 mg / kg / day, the course duration - at least 10 days.
For prevention of septic endocarditis in patients with heart defects, 1 g for adults and 20 mg / kg for children, 1 hour before the therapeutic or diagnostic procedure, then 0.5 g for adults and 10 mg / kg for children, again in 6 hours.
In whooping cough - 40-50 mg / kg / day for 5-14 days.
When pneumonia in children, 50 mg / kg / day in 4 divided doses, for at least 3 weeks.
When urogenital infections during pregnancy - 0.5 g 4 times a day for at least 7 days or (if the tolerance is poor) - 0.25 g 4 times a day for at least 14 days.
In adults, with uncomplicated clamidiosis and intolerance to tetracyclines - 0.5 g 4 times a day for at least 7 days.