Frequency of occurrence of side effects: very often -> 10%, often -> 1-10%, sometimes -> 0.1% - <1%, rarely -> 0.01-0.1%, very rarely - <0.01%, including individual messages.
On the part of the digestive system: often - nausea, vomiting, indigestion, constipation, diarrhea; sometimes pain in the abdominal region, stomatitis, dry mouth, increased activity of "liver" enzymes.
From the central and peripheral nervous system: often - headache, weakness; sometimes - depression, anxiety, drowsiness, insomnia, memory impairment, dysesthesia; rarely - irritability, nervousness, hyperesthesia, hypoesthesia.
From the hemopoietic system and lymphatic system: sometimes - a leukopenia.
From the cardiovascular system: sometimes - palpitation, tachycardia, thrombophlebitis, increased blood pressure (BP); rarely - embolism of the pulmonary artery, thrombosis of the arteries, cerebral circulation disorders.
From the respiratory system: sometimes - shortness of breath.
From the skin and skin appendages: often - alopecia, excessive sweating, skin rash; sometimes - itchy skin, dry skin, hives.
From the musculoskeletal system: often - myalgia, arthralgia, ossalgia, arthritis.
From the sense organs: sometimes - cataract, eye irritation, "blurring" of vision, a violation of taste sensations.
From the side of the urinary system: rarely - frequent urination.
On the part of the reproductive system: sometimes - vaginal bleeding, discharge from the vagina, dryness of the vagina.
Other: very often - paroxysmal sensations of heat ("hot flashes"), often - increased fatigue, asthenia, general malaise, peripheral edema, weight gain; sometimes - hypercholesterolemia, generalized edema, pain in tumor nodes, urinary tract infections; rarely - a fever, thirst, a decrease in body weight.