Adverse reactions in most cases are weak or moderately expressed and are mainly associated with suppression of the synthesis of estrogens.
Frequency of side effects: very often occurring - 1 out of 10 appointments (> 10% of patients), often - 1/100 appointments (> 1% and <10%), infrequently - 1/1000 appointments (> 0.1% and <1 %), rarely - 1/10000 appointments (> 0.01% and <0.1%), very rarely - 1/10000 prescriptions (<0.01%).
From the nervous system: often - headache, dizziness, a sense of chronic fatigue (asthenia); infrequently - anxiety, nervousness, irritability, drowsiness, insomnia, memory impairment, dysesthesia, hypoesthesia, impaired taste, cerebral circulation, depression, paresthesia, carpal tunnel syndrome.
From the side of the organ of vision: infrequently - cataract, eye irritation, visual impairment.
From the cardiovascular system: infrequently - sensation palpitations, tachycardia, thrombophlebitis of the superficial and deep veins, increased blood pressure, coronary heart disease (angina, myocardial infarction, heart failure), thromboembolism; rarely - embolism of the pulmonary artery, thrombosis of the arteries, stroke.
On the part of the hematopoiesis system: infrequently, leukopenia.
From the respiratory system, chest and mediastinum: infrequently - shortness of breath, cough.
From the digestive system: often - nausea, vomiting, dyspepsia, constipation, diarrhea, anorexia, increased appetite; infrequently - pain in the abdomen, stomatitis, a feeling of dryness in the mouth.
From the liver and bile ducts: infrequently - increased activity of "liver" transaminases; very rarely - hepatitis.
From the skin and subcutaneous tissues: often - alopecia, dry skin, vesicular and psoriasis-like rash; frequency unknown - angioedema, Lyell's syndrome (toxic epidermal necrolysis), Stevens-Johnson syndrome (malignant polymorphic exudative erythema).
From the genitourinary system: infrequently - vaginal dryness, pain in the mammary glands, vaginal bleeding, leukorrhea, frequent urination, urinary tract infections.
From the musculoskeletal system: very often - arthralgia; often - myalgia, bone pain, osteoporosis, bone fractures; infrequently - arthritis; frequency is unknown - a snapping finger syndrome.
Allergic reactions: often - skin rash (including erythematous and maculopapular), infrequently - skin itching, hives, anaphylactic reactions.
Benign, malignant and unspecified neoplasms (including cysts and polyps): infrequently - pain in tumor foci.
Other: very often - paroxysmal sensations of heat (hot flashes); often - peripheral edema, weight gain,hypercholesterolemia; infrequently - weight loss, increased sweating, generalized edema, dry mucous membranes, thirst, fever.