The adverse reactions listed below are presented in accordance with the classification of the medical vocabulary for regulatory activities MedDra and with the frequency of occurrence: very often (≥1 / 10); often (from ≥1 / 100 to <1/10); infrequently (from ≥1 / 1000 to <1/100); rarely (from ≥1 / 10000 to <1/1000); very rarely (<1/10000), an unknown frequency (based on the available data - it is impossible to assess). Within each group, side effects are listed in descending order of severity.
Surveys
Often: weight gain;
Infrequently: weight loss.
From the side of the heart and vascular system
Infrequent: heart failure, angina pectoris, myocardial infarction, tachycardia, palpitation, thromboembolism; thrombophlebitis, including thrombophlebitis of superficial and deep veins, arterial hypertension;
Rarely: cerebral infarction, thromboembolism of the pulmonary artery, thrombosis of the arteries.
On the part of the blood and lymphatic system
Infrequent: leukopenia.
From the nervous system
Often: headache, dizziness;
Infrequent: acute disturbance of cerebral circulation; sensitivity disorders, including paresthesia and hypoesthesia; drowsiness, insomnia, memory disorder, taste disorders.
From the side of the organ of vision
Infrequent: cataract, eye irritation, blurred vision.
On the part of the respiratory system, the chest and mediastinal organs
Infrequently: dyspnoea, cough.
From the digestive system
Often: nausea, vomiting, indigestion, constipation, diarrhea;
Infrequent: abdominal pain, stomatitis, dry mouth.
From the urinary system
Infrequent: frequent urination.
From the skin and subcutaneous tissue
Very often: increased sweating;
Often: alopecia, rash, including erythematous, maculopapular, psoriiform, vesicular;
Infrequent: itchy skin, dry skin, urticaria rash.
From the musculoskeletal system and connective tissue
Very often: arthralgia;
Often: osteoporosis, fractures, bone pain, myalgia;
Infrequent: arthritis.
Metabolic and nutritional disorders
Often: anorexia, hypercholesterolemia, increased appetite;
Unclean: total swelling.
Infectious and parasitic diseases
Infrequently: an infection.
Neoplasms are benign, malignant, unspecified (including cysts and polyps)
Infrequent: pain in the area of the tumor (not with adjuvant or neoadjuvant).
Systemic disorders and complications at the site of administration
Very often: hot flashes, fatigue, including asthenia;
Often: peripheral edema, malaise;
Infrequently: hyperthermia, dryness of mucous membranes, thirst.
From the hepatobiliary system
Infrequently: increased activity of "hepatic" enzymes.
From the side of the reproductive system and mammary glands
Infrequent: bleeding from the vagina, discharge from the vagina, dryness of the vagina, soreness of the mammary glands.
Disorders of the psyche
Often: depression.
Infrequently: anxiety, including nervousness, irritability.