As a rule, adverse reactions were mild or moderate and mainly related to suppression of the synthesis of estrogens.
The incidence of adverse reactions is estimated as follows: arising "very often" -> 10%, "often" -1-10%, "sometimes" - 0.1-1%, "rarely" - 0.01-1.1% , "very rarely" - <0.01%, including individual messages.
On the part of the digestive system: often - nausea, vomiting, indigestion / constipation, diarrhea; sometimes abdominal pain, stomatitis, dry mouth, increased activity of "liver" enzymes.
From the nervous system: often - headache, dizziness, depression; sometimes - anxiety, nervousness, irritability, drowsiness, insomnia, memory impairment, dysesthesia, paresthesia, hypesthesia, eating disorders, episodes of cerebral circulation disorders.
From the hematopoiesis: sometimes - a leukopenia.
From the cardiovascular system: sometimes - heart palpitations, tachycardia, thrombophlebitis of the superficial and deep veins, increased blood pressure (BP), ischemic heart disease (angina, myocardial infarction, cardiac insufficiency), thromboembolism; rarely - embolism of the pulmonary artery, thrombosis of the arteries, stroke.
From the respiratory system: sometimes - shortness of breath, cough.
From the skin and skin appendages: often - alopecia, excessive sweating, skin rash, (including erythematous, maculopapular, vesicular rash, psoriasis-like rashes); sometimes itching, dry skin, urticaria; highly rarely - angioedema, anaphylactic reactions.
From the musculoskeletal system: very often - arthralgia; often - myalgia, pains in bones, osteoporosis, fractures of bones, sometimes - arthritis.
From the sense organs: sometimes - cataract, eye irritation, "blurring" of vision, a violation of taste sensations.
From the side of the urinary system: sometimes - frequent urination of urinary tract infection.
On the part of the reproductive system: sometimes - vaginal bleeding, vaginal discharge, vaginal dryness, pain in the mammary glands.
Other: very often - paroxysmal sensations of heat ("hot flashes"); often - increased fatigue, asthenia, malaise, peripheral edema, increase body weight, hypercholesterolemia, anorexia, increased appetite; sometimes - weight loss, thirst, hyperthermia (pyrexia), dry mucous membranes, generalized edema, pain in tumor foci.