The frequency of side effects: very often - ≥10%, often ≥1-10%, sometimes ≥0.1% - <1%, rarely ≥0.01-0.1%, very rarely - <0.01%, including individual reports.
From the side of the digestive system: often - nausea, vomiting, anorexia, dyspepsia, constipation, diarrhea; sometimes - pain in the abdominal region, stomatitis, dry mouth, increased activity of "liver" enzymes; very rarely - hepatitis.
From the central and peripheral nervous system: often - headache, dizziness, weakness, depression; sometimes - anxiety, irritability, drowsiness, insomnia, memory impairment, dysesthesia, nervousness, hypesthesia, paresthesia, eating disorders; rarely - hyperesthesia.
On the part of the hematopoiesis and lymphatic system: sometimes - leukopenia.
From the side of the cardiovascular system: sometimes - thrombophlebitis of deep and superficial veins, angina pectoris, myocardial infarction, heart failure, palpitations, tachycardia, thromboembolism, increased blood pressure; rarely - embolism of the pulmonary artery, thrombosis of the arteries, cerebral circulation disorders.
From the respiratory system: sometimes - shortness of breath, cough.
From the skin and skin appendages: often - alopecia, excessive sweating, skin rash (including erythematous, maculopapular, vesicular rash, psoriasis-like rashes); sometimes - itchy skin, dry skin, urticaria; very rarely - angioedema, anaphylactic reactions, Lyell's syndrome (toxic epidermal necrolysis), Stevens-Johnson syndrome (erythema multiforme).
From the musculoskeletal system: very often - arthralgia; often - myalgia, bone pain, osteoporosis, bone fractures; sometimes - arthritis.
From the sense organs: sometimes - cataract, eye irritation, "clouding" of vision, a violation of taste sensations.
From the side of the urinary system: sometimes - frequent urination, urinary tract infections.
From the side of the reproductive system: sometimes - vaginal bleeding, vaginal discharge, vaginal dryness, pain in the mammary glands.
Other: very often - paroxysmal sensations of heat ("hot flashes"), often - increased appetite, hypercholesterolemia, fatigue, asthenia, general malaise, peripheral edema, weight gain; sometimes - thirst, dry mucous membranes, generalized edema,pain in the tumor nodes, urinary tract infection; rarely - a febrile state, a decrease in body weight.