As a rule, adverse reactions were mild or moderate and mainly related to suppression of the synthesis of estrogens (eg, flushing of the face, alopecia and vaginal bleeding).
The incidence of adverse reactions is distributed as follows:
Often (> 1/10), often (> 1/100, <1/10), sometimes (> 1/1000, <1/100), rarely (> 1/10000, <1/1000), rarely (<1/10000), frequency is not known.
Infectious and parasitic diseases
Sometimes - urinary tract infections
Benign, malignant and unspecified neoplasms, (including cysts and polyps)
Sometimes - pain in tumor foci (not applicable with adjuvant and prolonged adjuvant treatment).
Violations of the blood and lymphatic system
Sometimes - leukopenia.
Disorders from the metabolism and nutrition
Often - anorexia, increased appetite, hypercholesterolemia;
sometimes - generalized edema.
Disorders of the psyche
Often - depression;
sometimes - anxiety, including nervousness and irritability.
Disturbances from the nervous system
Often - headache, dizziness;
sometimes - drowsiness, insomnia, memory impairment; Sensitivity disorder (dysesthesia), including paresthesia; hypoesthesia, violation of taste sensations, episodes of cerebral circulation disorders.
Disturbances on the part of the organ of sight
Sometimes - cataract, eye irritation, blurred vision.
Heart Disease
Sometimes - palpitation, tachycardia.
Vascular disorders
Sometimes - thrombophlebitis, including thrombophlebitis of the superficial and deep veins, arterial hypertension, ischemic heart disease;
rarely - pulmonary embolism, arterial thrombosis, stroke.
Disturbances from the respiratory system, chest and mediastinal organs
Sometimes - shortness of breath, cough.
Disorders from the gastrointestinal tract
Often - nausea, vomiting, indigestion, constipation, diarrhea;
sometimes - abdominal pain, stomatitis, dry mouth.
Disturbances from the liver and bile ducts
Sometimes - increased activity of hepatic enzymes.
Disturbances from the skin and subcutaneous tissues
Often - increased sweating;
often - alopecia; rash, including erythematous, maculopapular, vesicular rash; psoriasis-like rashes,
sometimes - itching, dry skin, urticaria;
frequency not known - angioedema - edema, anaphylactic reactions.
Disturbances from musculoskeletal and connective tissue
Often - arthralgia;
often - myalgia, bone pain, osteoporosis, fractures of bones;
sometimes - arthritis.
Disorders from the kidneys and urinary tract
Sometimes - Frequent urination.
Violation of the genitals and mammary gland
Sometimes - vaginal bleeding, discharge from the vagina, dryness of the vagina, pain in the mammary glands.
General disorders and disorders at the site of administration
Often - flushes of blood, fatigue, including asthenia;
often - malaise, peripheral edema;
sometimes - hyperthermia, dryness of the mucous membrane, thirst.
Impact on the results of laboratory and instrumental studies
Often - increase in body weight;
sometimes - decrease in body weight.