Undesirable reactions are listed according to the frequency of their registration in accordance with the following gradation highly often (> 10%); often (> 1% and <10%); infrequently (> 0.1% and <1%); rarely (> 0.01% and <0.1%); very rarely (<0.01%), including individual messages
From the digestive system: often - nausea, vomiting, indigestion, constipation, diarrhea, anorexia, infrequently - abdominal pain, stomatitis, dry mouth, increased activity of "liver" enzymes; very rarely - hepatitis.
From the nervous system: often - headache, dizziness, depression; infrequently - a sense of anxiety, nervousness, irritability, drowsiness, insomnia, memory impairment, dysesthesia, paresthesia, hypoesthesia, eating disorders, episodes of cerebral circulation disorders.
From the hematopoiesis: infrequently, leukopenia.
From the side of the cardiovascular system: infrequent - palpitation, tachycardia, thrombophlebitis of superficial and deep veins, increased blood pressure, ischemic cardiovascular disorders (angina pectoris, myocardial infarction, heart failure); rarely - thromboembolism, pulmonary embolism, thrombosis of the arteries, stroke.
From the side respiratory system: infrequently - shortness of breath, cough.
From the skin and subcutaneous fat: often - alopecia, excessive sweating, skin rash (including erythematous, maculopapular, vesicular rashes, psoriasis-like rashes); infrequently - itching of the skin, dry skin, urticaria; very rarely - angioedema, anaphylactic reactions, Lyell's syndrome (toxic epidermal necrolysis), (malignant exudative erythema).
From the musculoskeletal system: very often - arthralgia; often - myalgia, ossalgia, osteoporosis, fractures of bones; infrequently - arthritis.
From the sense organs: infrequently - cataract, eye irritation, blurred vision, violation of taste sensations.
From the genitourinary system: infrequent - frequent urination, urinary tract infections, vaginal bleeding, vaginal discharge, vaginal dryness, pain in the mammary gland.
Other: very often - the "tides" of blood; often - increased fatigue, asthenia, malaise, peripheral edema, weight gain, increased appetite; infrequently - weight loss, hypercholesterolemia, thirst, hyperthermia, dry mucous membranes, generalized edema, pain in tumor foci.