The frequency of side effects: very often - ≥10%, often - ≥1-10%, sometimes - ≥0.1% - <1%, rarely - ≥0.01-0.1%, very rarely - <0.01%, including individual messages.
On the part of the digestive system: often - nausea, vomiting, indigestion, constipation, diarrhea; sometimes - pain in the abdominal region, stomatitis, dry mouth, increased activity of "liver" enzymes; very rarely - hepatitis.
From the central and peripheral nervous system: often - headache, weakness, depression, irritability; sometimes - nervousness, hypoesthesia, anxiety, drowsiness, insomnia, memory impairment, dysesthesia; rarely - hyperesthesia.
From the hemopoietic system and lymphatic system: sometimes - a leukopenia.
From the cardiovascular system: sometimes - a feeling of palpitations, tachycardia, deep and superficial venous thrombophlebitis, increased blood pressure (BP), angina pectoris, myocardial infarction, heart failure; rarely - pulmonary embolism, thrombosis of the arteries, cerebral circulation disorders.
From the respiratory system: sometimes - shortness of breath, cough.
From the skin and skin appendages: often - alopecia, increased sweating, skin rash (erythematous, maculopapular, vesicular, psoriasis-like); sometimes - itchy skin, dry skin, urticaria; rarely - angioedema, anaphylactic reactions, Lyell's syndrome, Stephen-Johnson syndrome.
From the musculoskeletal system: very often - arthralgia; often - myalgia, ossalgia, osteoporosis, fractures of bones; sometimes - arthritis.
From the sense organs: sometimes - cataract, eye irritation, "misting" sight, a violation of taste.
From the side of the urinary system: sometimes - frequent urination.
On the part of the reproductive system: sometimes - pain in the mammary glands, vaginal bleeding, vaginal discharge, dryness of the vagina.
Other: very often - paroxysmal sensations of heat ("hot flashes"), often - increased fatigue, asthenia, general malaise, peripheral edema, weight gain, hypercholesterolemia, increased appetite; sometimes - thirst, weight loss, pain in the tumor nodes, urinary tract infection; rarely - a febrile state.