Ceftazidime is administered intravenously (either jet or drip) or intramuscularly (should be injected into large muscles). The dose of the drug is determined individually, taking into account the severity of the disease, localization of infection and sensitivity of the pathogen, age and body weight, kidney function.
The duration of treatment is 7-14 days. In infections caused by Pseudomonas aeruginosa (pneumonia, in patients with cystic fibrosis, meningitis), the course of treatment can be increased to 21 days.
Usual dose for adults and children over 12 years of age:
- usually prescribed 1.0 g every 8 hours or 2.0 g every 12 hours;
- with complicated infections of the urinary tract intramuscularly or intravenously, 500 mg - 1 g every 8-12 hours;
- with uncomplicated pneumonia and skin infections intramuscularly or intravenously, 500 mg - 1 g every 8 hours;
- in cystic fibrosis, lung infections caused by Pseudomonas spp. from 100 to 150 mg / kg / day, the frequency of administration - 3 times a day (dose up to 9 g / day in such patients did not cause complications);
- at infections of bones and joints intravenously on 2 g every 12 h;
- with extremely severe or life-threatening infections (including patients with neutropenia) intravenously 2 g every 8 hours;
- in chronic renal failure: patients with severe infections can increase the maintenance dose by 50% or the frequency of drug administration;
- In elderly patients, the recommended dose of ceftazidime should not exceed 3 g / day, especially in patients older than 80 years.
After an initial dose of 1 g, adults with impaired renal function (including patients who undergo dialysis), a dose reduction may be required, such as is as follows:
| CREATINE CREATININE | DOSE |
| >50 ml / min (0.83 ml / sec) | See section "Usual dose for adults and children over 12 years of age" |
| 31-50 ml / min (0.52-0.83 ml / sec) | 1 g every 12 h |
| 16-30 ml / min (0.27-0.50 ml / s) | 1 g every 24 h |
| 6-15 ml / min (0.10 to 0.25 ml / s) | 500 mg every 24 hours |
| <5 ml / min (0.08 ml / s) | 500 mg every 48 hours |
| Patients undergoing hemodialysis | 1 g after each session hemodialysis |
| Patients undergoing peritoneal dialysis | 500 mg every 24 hours |
These indicators are approximate. In such patients it is recommended to monitor the concentration of ceftazidime in serum, which should not exceed 40 mg / l.
The half-life of ceftazidime during hemodialysis is 3 to 5 hours.
The maintenance dose should be repeated after each dialysis period.
When peritoneal dialysis a drug ceftazidime can be included in dialysis
liquid in a dose of 125 mg to 250 mg per 2 liters of dialysis fluid.
Usual dose for children under 12 years:
Demu in the age of up to 2 months. - intravenous infusion 25-60 mg / kg / day per day in 2 divided doses.
Children from 2 months. and up to 12 years - intravenous infusion of 30 - 100 mg / kg per day (the frequency of administration 2-3 times a day).
Children with immunity, cystic fibrosis and meningitis the drug can be prescribed in doses up to 150 mg / kg / day (maximum daily dose is 6.0 g) in 3 divided doses,
The maximum daily intake for children should not exceed 6 g in 3 divided doses.
PREPARATION OF SOLUTIONS
1. "PRIMARY" BREEDING
| 2.0 g | | 3 ml of water for injection | 10 ml of water for injection |
| | | with intramuscular | for intravenous |
| | | administered. | administered. |
In the prepared solution, small bubbles of carbon dioxide may be present, which does not affect the effectiveness of the preparation.
2. "SECONDARY" BREEDING
For intravenous DROPS introduction, the preparation solution prepared in the manner described above ceftazidime further dilute in 50 - 100 ml of one of the following solvents intended for intravenous administration:
- 0.9% solution of sodium chloride;
- Ringer's solution;
- l Ringer's activated solution;
- 5% dextrose solution;
- 5% dextrose solution, 0.9% sodium chloride solution;
- 10% solution of dextrose.
During the dilution the vials with the preparation should be vigorously shaken until the contents are completely dissolved. Before introducing the solution, you should visually check that there are no foreign particles or sediment.