Intravenously, infusion. The dose of the drug is determined individually, taking into account the severity of the disease, localization of infection and sensitivity of the pathogen, age and body weight, kidney function.
Adults and children over 12 years of age are prescribed 1 g every 8-12 h or 2 g at intervals of 12 h.
In severe disease, especially in patients with reduced immunity, including patients with neutropenia,should be assigned to 2 g every 8 or 3 g every 12 h.
With complicated infections of the urinary tract - 0.5 g -1 g 2 times a day. In cystic fibrosis, patients with respiratory system infections caused by Pseudomonas spp., 100-150 mg / kg / day, the frequency of administration is 3 times a day.
In operations on the prostate gland, prophylaxis is administered before the induction of anesthesia, 1 g, the administration is repeated after removal of the catheter. Older patients, taking into account the lowered clearance of ceftazidime in acute diseases, the maximum daily dose is 3 g, especially for patients older than 80 years.
Children older than 2 months and up to 12 years of age are prescribed 30-100 mg / kg / day (2-3 administrations), children with reduced immunity, cystic fibrosis and meningitis -150 mg / kg / day in 3 injections, the maximum daily dose is 6 Newborns and infants up to 2 months of age are prescribed 25-60 mg / kg / day in 2 injections.
If the renal function is impaired, the initial dose is 1 g. The maintenance dose is selected depending on the rate of creatinine release: when creatinine clearance is 50-31 ml / min - 1 g 2 times a day, 30-16 ml / min -1 g 1 once a day, 15-6 ml / min - 0.5 g once a day; less than 5 ml / min - 0.5 g once every 48 hours. For patients with infections of severe course, a single dose can be increased by 50%, while they should control the concentration of ceftazidime in the serum (should not exceed 40 mg / l).
For children, the clearance of creatinine is calculated in accordance with the ideal body weight or surface area of the body.
Against the background of hemodialysis, maintenance doses are calculated taking into account the clearance of creatinine (CC), the administration is performed after each hemodialysis session. Against the background of peritoneal dialysis, in addition to intravenous administration
ceftazidime can be included in the dialysis solution (125-250 mg per 2 liters of dialysis solution). In patients with renal insufficiency, on continuous hemodialysis using an arteriovenous shunt, and in patients who are on high-speed haemofiltration in the intensive care unit, the recommended dose is 1 g / day daily (for one or more injections).
Patients on low-speed haemofiltration are prescribed doses recommended for renal dysfunction.
Duration of treatment
The duration of treatment with ceftazidime is 7-14 days. In infections caused by Pseudomonas aeruginosa (pneumonia, cystic fibrosis, meningitis), treatment can be increased up to 21 days.
Rules for the preparation of a solution for infusions.
Use only freshly prepared solution! After adding the solvent, the vial should be vigorously shaken until the powder is completely dissolved.
In the prepared solution, small bubbles of carbon dioxide may be present, which does not affect the effectiveness of the preparation.
Light yellowing of the solution does not affect the effectiveness of the preparation.
2000 mg is dissolved in 3 ml of water for injection. The resulting solution of the preparation is further diluted to 50 ml or 100 ml by one of the infusion solutions listed below:
water for injection, 0.9% solution of sodium chloride, Ringer's solution, 5% dextrose (glucose) solution, 10% dextrose (glucose) solution, 0.9% sodium chloride solution and 5% dextrose.