Apply intravenously or intramuscularly.
The dose of the drug is determined individually depending on the severity of the course of the disease, the localization of infection and the sensitivity of the pathogen, age and body weight, the function of the patient's kidneys.
Usual dose for adults and children over 12 years of age
In severe infections, especially in patients with reduced immunity (including patients with neutropenia) - 2 g every 8 hours.
In cystic fibrosis, infections of the respiratory system caused by Pseudomonas spp. - 100-150 mg / kg / day, the frequency of administration - 3 times a day.
With infections of the urinary tract and infections of the lung current - 0.5-1 g 2 times a day.
With uncomplicated pneumonia and skin infections - 0.5-1 g every 8 hours. For infections of bones and joints - 2 g every 12 hours.
When surgery on the prostate gland is prescribed at a dose of 1 g during an introductory anesthesia, repeat the introduction after removal of the catheter.
The duration of treatment with ceftazidime is 7-14 days. With infections caused by R. aeruginosa (pneumonia, purulent complications of cystic fibrosis, meningitis), the course of treatment can be increased up to 21 days.
If the kidney function is disturbed after the initial dose -1g correction of the dosing regimen is necessary. The maintenance dose is selected depending on the creatinine clearance: when creatinine clearance is 50-31 ml / min - 1 g 2 times a day, 30-16 ml / min - 1 g 1 time per day, 15-6 ml / min - 0.5 g once daily, less than 5 ml / min - 0.5 g every 48 hours.
Against the background of hemodialysis, maintenance doses are calculated taking into account the clearance of creatinine, the administration of a suitable dose of the drug is carried out after each hemodialysis session. Against the background of peritoneal dialysis, in addition to intravenous administration ceftazidime can be included in the dialysis solution (125-250 mg per 2 L).
Usual dose for children
Newborns and infants under 2 months of age: intravenous infusion at a dose of 25-60 mg / kg / day in 2 divided doses.
Children from 2 months to 12 years: intravenous infusion at a dose of 30-100 mg / kg / day in 2-3 divided doses. Children with reduced immunity, cystic fibrosis and meningitis: intravenous infusion up to 160 mg / kg / day, every 8 hours.
The maximum daily dose for children should not exceed 6 g.
Patients older than 80 years, the maximum daily dose should not be more than 3 g.
Rules for the preparation of solution for injection
To prepare a solution for injection, 1 g of the drug is dissolved in 3 ml of water for injection (with intramuscular injection) and 10 ml of water for injection (with intravenous administration).For IV injection, the resulting solution is diluted in 50-100 ml of the solvent. For the / m introduction ceftazidime can be diluted with a solution of lidocaine hydrochloride 1%.
In the prepared solution, small bubbles of carbon dioxide may be present, which does not affect the effectiveness of the preparation. Use only freshly prepared solution. Light yellowing of the solution does not affect the efficiency.