Vicef® is administered parenterally - intra / w and / m.
In adults and children over 12 years of age Vitsefa® usual single dose of 1 g every 8-12 hours, or 2 g to 12 hours apart. The following doses, multiplicity and routes of administration are also recommended, which are determined by the localization and severity of the disease:
- for uncomplicated urinary tract infections - 0.25 g every 12 hours in / in or / m;
- with complicated infections of the urinary tract - 0.5 g every 8 or 12 hours in / in or / m;
- with uncomplicated pneumonia, infections of the skin and soft tissues, infections of LOP-organ - 0.5-1 g every 8 hours iv or m;
- with severe intra-abdominal or gynecological infections - 2 g every 8 hours IV;
- with infections of bones and joints - 2 g every 12 hours in / in;
- at a bacterial meningitis - on 2 g every 8 hours in / in;
- in severe, life-threatening infections and febrile neutropenia - 2 g every 8 hours / in, or 3 g every 12 hours / in (maximum daily dose-d 6);
- with severe pulmonary infection caused by Pseudomonas aeruginosa, in patients with cystic fibrosis and normal renal function - 30-50 mg / kg every 8 hours in / in.
For the antibiotic prophylaxis of postoperative complications in operations on the prostate gland for Vitsefa®, when removing the urinary catheter, it is recommended to re-enter 1 g of Vitsef®.
Children over 1 month. and up to 12 years usually administered at 30-50 mg / kg every 8 hours. For the treatment of bacterial meningitis, as well as treatment of infections in children with immunodeficiency or cystic fibrosis, the daily dose is 150 mg / kg (but not more than 6 g per day), which is divided into 3 injections.
Newborns (children up to 1 month old) appoint 30 mg / kg every 12 hours in / in.
Patients with impaired renal function require dose adjustment and administration regimens based on creatinine clearance. Treatment begins with the administration of 1 g of Vitsef® as the first loading dose. In the future, the supporting mode calculated as shown in the table:
| CK, ml / min | 50-31 | 30-16 | 15-5 | <5 |
| Mode | 1 g every 12 hours | 1 g every 24 h | 0.5 g every 24 hours | 0.5 g every 48 h |
For patients with severe infections in the background of chronic renal failure, the single doses indicated in the table (see above) can be increased by 50%, or the intervals between administrations can be shortened.In the future, correction of the dosing regimen is carried out based on sensitivity data of the isolated microorganisms, severity of the patient's condition and therapeutic monitoring data concentrations of ceftazidime in serum (the residual concentration should not exceed 40 mg / l).
When hemodialysis: loading dose - 1 g, then 1 g after each hemodialysis procedures. When continuous hemodialysis using an arterio-venous shunt and with high-speed hemofiltration - 1 g / day daily (for one or more injections). When performing hemofiltration with a low rate, Vitsef® is prescribed in doses recommended for renal dysfunction (see table above). With peritoneal dialysis, 1 g (loading dose) is first administered, then 0.5 g once every 24 hours. In addition to intravenous or intravenous administration, it is possible to administer Vitsef® as part of a dialysis solution at the rate of 0.25 g of Vitsef® per 2 liters of dialysis solution. The introduction of Vitsef should be continued for another 2 days after the disappearance of the symptoms of infection. In cases of severe and complicated infections, a long course of treatment may be required.
Vicef® is administered intravenously (by jet, drip) and by intramuscular injection.
The dissolution of Vitsef® is accompanied by a slight exothermic reaction, in which carbon dioxide is released and a positive pressure is created in the vial. Carbon dioxide bubbles can be present in the finished solution, which does not affect the effectiveness of the drug. Light yellowing of the solution does not affect the efficiency.
Intramuscular injection
For intravenous administration, sterile Vietsef® powder is dissolved in sterile water for injection or a 0.5-1% solution of lidocaine hydrochloride (in the absence of indications of intolerance to local anesthetics of the amide type). The following minimum amounts of solvent are added directly to the bottle with a dry antibiotic powder:
into a vial containing 0.5 g of Vitsef® 1.5 ml
into a vial containing 1.0 g of Vitsef® 3.0 ml
The resulting solution, an approximate concentration of ceftazidime in which 260 mg / ml, is administered intramuscularly to areas of the body with a pronounced muscular layer (upper to outer quadrant of the buttock or lateral surface of the thigh). It is recommended that an aspiration test be carried out to avoid undesirable introduction of the solution into the blood vessel.
Intravenous administration
For intravenous administration, Vitsef® is dissolved in sterile water for injection. The following amounts of solvent are added directly into the bottle with a dry powder of antibiotic:
in a vial containing 0.5 g of Vitsef® 5.0 ml
in a vial containing 1.0 g of Vitsef® 10 ml
in a vial containing 2.0 g of Vitsef® 20 ml
The resulting solution, an approximate concentration of ceftazidime in which 90 mg / ml, is administered ip slowly, for 3-5 minutes; it is possible to administer through a special node or port for injection of a system for intravenous infusions if the patient receives parenterally-compatible liquids with Vitsef®. For IV infusion, Vitsef® is dissolved, as for IV injections (see above). The resulting solution is added to a vial containing 50-100 ml of a compatible infusion medium. Enter through the system for IV infusions for at least 30 minutes. Vitsef® is compatible with 5% dextrose solution, 0.9% sodium chloride solution, 10% dextrose solution, an aqueous solution containing 0.225% sodium chloride and 5% dextrose; an aqueous solution containing 0.45% sodium chloride and 5% dextrose; an aqueous solution containing 0.9% sodium chloride and 5% dextrose; Ringer's solution;lactated Ringer's solution; 1/6 M sodium lactate solution; 10% solution of invert sugar; solution of "Normozol-M" with 5% glucose.