The drug is administered intravenously or intramuscularly. The dose of the drug is determined individually, taking into account the severity of the disease, localization of infection and sensitivity of the pathogen, age and body weight, kidney function.
Adults and children over 12 years of age appoint 1 g every 8-12 hours or 2 g at intervals of 12 hours.In severe infections, especially in patients with reduced immunity (including patients with neutropenia), - 2 g every 8 hours or 3 g every 12 hours. In uncomplicated urinary tract infections - 0.25 g 2 times a day. With complicated infections of the urinary tract - 0.5-1 g 2 times a day. In cystic fibrosis, patients with respiratory infections caused by pseudomonas spp. - 30-50 mg / kg every 8 hours. In operations on the prostate gland, prophylaxis is administered before the induction of anesthesia, 1 g, the administration is repeated after removal of the catheter.
Elderly patients with a maximum daily dose of 3 g.
Children over 2 months. and up to 12 years appoint 30-100 mg / kg / day (for 2-3 injections), the maximum dose - 6 g / day; children with reduced immunity, cystic fibrosis and meningitis - 150 mg / kg / day in 3 injections, the maximum daily dose - 6 g.
Newborns and infants under 2 months of age. prescribe 25-60 mg / kg / day in 2 injections.
If the kidney function is disturbed, the initial dose is 1 g. The maintenance dose is selected depending on the rate of excretion as indicated below.
CREATINE CREATININE DOSE
31-50 ml / min. 1 g every 12
16-30 ml / min. 1 g every 24 h
5-15 ml / min. 500 mg every 24 hours
<5 ml / min, 500 mg every 48 hours
For patients with severe infections, a single dose can be increased by 50%, while they should control the concentration of ceftazidime in the serum (should not exceed 40 mg / l).
For children, the clearance of creatinine is calculated in accordance with the ideal body weight or surface area of the body.
Against the background of hemodialysis, maintenance doses are calculated taking into account the clearance of creatinine, the administration is performed after each hemodialysis session. Against the background of peritoneal dialysis, in addition to intravenous administration ceftazidime can be included in the dialysis solution (125-250 mg per 2 liters of dialysis solution). In patients with renal insufficiency, on continuous hemodialysis using an arteriovenous shunt, and in patients who are on high-speed haemofiltration in the intensive care unit, the recommended dose is 1 g / day daily (for one or more injections).
Patients on low-speed haemofiltration are prescribed doses recommended for renal dysfunction.
The maximum daily intake for adults and children should not exceed 6 g. The duration of treatment with ceftazidime is 7-14 days. In infections caused by Pseudomonas aeruginosa (pneumonia, infectious complications of cystic fibrosis, meningitis) treatment course can be increased up to 21 days.
Preparation of solutions
1 . "Primary" breeding
1.0 g 3 ml water for injection with 10 ml water for injection at
intramuscular administered. intravenous administration.
2. "Secondary" breeding
Day of intravenous drip The preparation solution obtained in the above described way is further diluted in 50-100 ml of one of the following solvents intended for intravenous administration:
- 0.9% solution of sodium chloride,
- solution of Hartmann,
-5% and 10% dextrose (glucose) solution,
- 5% dextrose (glucose) solution with 0.9% sodium chloride solution,
Use only freshly prepared solution!