Heparin 1000 - instructions for use, doses, side effects, contraindications

Excipients: methyl parahydroxybenzoate 0.150 g, ethanol 95% 24,000 g, carbomer 1,000 g, trometamol 0.500 g, orange flower oil 0.025 g, lavender oil 0.025 g, water up to 100,000 g.

Description:Colorless or slightly yellowish tinge, almost transparent gel with a characteristic odor.

Pharmacotherapeutic group:Anticoagulant direct action for topical application

ATX: & nbsp

B.01.A.B.01 Heparin

Pharmacodynamics:

Heparin sodium - an anticoagulant of direct action, belongs to the group of medium-molecular heparins. Prevents thrombosis, promotes regeneration of connective tissue due to inhibition of hyaluronidase activity; activates the fibrinolytic properties of the blood.

With external application has a local antithrombotic effect; anti-edematous and anti-inflammatory action,improves blood microcirculation and activates tissue metabolism, as a result of which the processes of resorption by hematomas are accelerated, prevents the formation of thrombi, reduces puffiness tissues.

Pharmacokinetics:

With external application, a small amount of heparin penetrates into the systemic blood stream, without having a systemic effect, without causing any changes in blood coagulation parameters. Heparin does not penetrate the placental barrier.

Indications:

- diseases of superficial veins: varicose veins, chronic venous insufficiency and associated complications (superficial thrombophlebitis, superficial periphlebitis);

- blunt injuries and bruises of soft tissues;

- subcutaneous hematomas, including hematomas after vein operations, phlebectomy;

- localized infiltrates and swelling of soft tissues.

Contraindications:

- hypersensitivity to the components of the drug;

- violation of the integrity of the skin at the site of application (open wounds, ulcerative necrotic lesions);

- increased tendency to bleeding, thrombocytopenia;

- age to 18 years (safety and efficacy of the drug not studied).

Pregnancy and lactation:

The use of the drug Heparin 1000 is not contraindicated in pregnancy and during breastfeeding.

Heparin sodium does not penetrate the placental barrier and into breast milk. Due to the insignificant absorption of heparin during external application, the drug does not have systemic effects on the body. However, before using the drug, you should consult your doctor.

Dosing and Administration:

For external use.

A small amount of gel (3-10 cm) 1-3 times a day is applied a thin layer on the skin and gently rubbed.

With localized consequences of injuries and bruises (hematoma, infiltration, edema of soft tissues) until the symptoms disappear.

With initial symptoms of venous insufficiency ("heaviness", pain in the legs, venous swelling) apply within 1-3 weeks depending on the severity of the symptoms.

With varicose veins and complications of chronic venous insufficiency (superficial periphlebitis, superficial thrombophlebitis) should be applied within 4-6 weeks, depending on the severity of the symptoms of the disease.

The need for further treatment is determined by the doctor.

Side effects:

In some cases, hypersensitivity reactions may occur to the components of the drug, manifested by reddening of the skin and / or skin itching, which usually pass after discontinuation of the drug.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Very low systemic absorption of the active ingredient of the drug when applied externally makes practically impossible overdose.

In case of an overdose, the action of heparin can be neutralized with a solution of protamine sulfate.

If an overdose occurs, seek medical help immediately!

Interaction:

It is not recommended to use simultaneously with topical preparations containing tetracyclines, antihistamines or non-steroidal anti-inflammatory drugs.

Special instructions:

Do not apply the drug Heparin 1000 to the mucous membranes, open wounds and apply in the presence of purulent lesions at the intended site of application of the gel.

With prolonged use of the drug on large areas of the skin and simultaneous use of anticoagulants of indirect action (warfarin, syncumar, etc.), prothrombin time and coagulation time should be monitored.

It is not recommended to use the drug Heparin 1000 for deep vein thrombosis.

The experience of using the drug in children under the age of 18 is absent.

Do not exceed the maximum periods and recommended doses of the drug without coordination with the doctor!

Effect on the ability to drive transp. cf. and fur:

Heparin 1000 does not affect the ability to drive vehicles and work requiring increased concentration of attention.

Form release / dosage:

Gel for external use 1000 IU / g.

Packaging:

For 30 or 50 grams of aluminum tubes.

Each tube, together with the instruction for use, is placed in a cardboard package (bundle).

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years.

Do not use the drug after the expiration date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-003851

Date of registration:21.09.2016

Expiration Date:21.09.2021

The owner of the registration certificate:ATOLL, LLC ATOLL, LLC Russia

Manufacturer: & nbsp

OZONE, LLC Russia

Information update date: & nbsp26.03.2017

Illustrated instructions

Instructions

Heparin 1000 (Heparin 1000)