Active substanceSodium HeparinSodium Heparin Similar drugsTo uncover Heparin solution in / in PC ALVILS, LTD. Russia Heparin solution in / in PC BINERGIYA, CJSC Russia Heparin solution in / in PC ELFA NPC, CJSC Russia Heparin gel externally TATHIMFARMPREPARATY, JSC Russia Heparin gel externally MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia Heparin solution in / in PC SLAVYANSKAYA APTEKA, LLC Russia Heparin solution in / in PC BELMEDPREPARATY, RUP Republic of Belarus Heparin solution in / in PC MOSCOW ENDOCRINE FACTORY, FSUE Russia Heparin solution in / in PC MICROGEN FGUP Scientific and Production Association Russia Heparin solution for injections SYNTHESIS, OJSC Russia Heparin solution in / in PC Kursk Biofactory - BIOK, FKP Russia Heparin gel externally GREEN DUBRAVA, CJSC Russia Heparin gel externally Promomed Rus, Open Company Russia Heparin 1000 gel externally ATOLL, LLC Russia Heparin J solution in / in PC JODAS EKSPOIM, LLC Russia Sodium Heparin solution in / in PC ELLARA, LTD. Russia Sodium Heparin solution in / in PC INDUKERN-RUS, OOO Russia Sodium Heparin solution in / in PC FarmSirma Soteks, ZAO Russia Heparin-Akrihin 1000 gel externally AKRIKHIN HFK, JSC Russia Heparin-sodium Brown solution in / in PC B. Brown Mehlungen AG Germany Heparin-Ferein® solution for injections BRYNTSALOV-A, CJSC Russia Lavenum® gel externally POLLO, LLC Russia Lyoton® 1000 gel externally A.Menarini Industry Pharmaceuticals Riunite S.L. Italy Trombles® gel externally NIZHFARM, JSC Russia Thrombogel 1000 gel externally BELMEDPREPARATY, RUP Republic of Belarus Dosage form: & nbspgel for external use. Composition:per 100 g:Active substance: heparin sodium with an activity of 120 IU / mg in terms of dry matter - 0.833 g;Excipients: carbomer 940 (carbopol 980) 1.3 g, methylprahydroxybenzoate (nipagin) 0.15 g, trometamol 1.0 g, lavender oil 0.1 g, polyester PE 240 5.0 g, ethyl alcohol 95% (ethanol) - 30.0 g, purified water - 61.617 g. Description:Colorless or slightly yellowish tinge almost transparent gel with a specific odor. Opalescence is allowed. Pharmacotherapeutic group:Anticoagulant is a direct action for topical application. ATX: & nbspB.01.A.B.01 Heparin Pharmacodynamics:Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effect. Reduces platelet aggregation, binds to antithrombin III, preventing the passage of prothrombin in thrombin. Oppresses the activity of thrombin.Reduces the activity of hyaluronidase, increases the fibrinolytic properties of the blood. Gel improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and thrombi, eventually restoring the permeability of veins, clinically it is accompanied by a pronounced analgesic and anti-inflammatory effect. Pharmacokinetics:An insignificant amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after the application. The elimination of heparin, mainly occurs through the kidneys, half-life of 12 hours. Indications:- thrombophlebitis of superficial veins;- localized infiltrates and edema of soft tissues;- subcutaneous hematomas (including hematomas after phlebectomy);- injuries and bruises of joints, tendons, muscle tissue. Contraindications:hypersensitivity to the components of the drug;- ulcerative necrotic changes of the skin in places of supposed application of gel;- traumatic violation of the integrity of the skin;- Children's age (the experience of using the drug is limited). Carefully:Increased tendency to bleeding, thrombocytopenia. Pregnancy and lactation:It is possible to use the drug during pregnancy and lactation, if the potential benefit to the mother exceeds the risk to the fetus and the baby. Dosing and Administration:Outwardly.Thrombophlebitis of superficial veins.3-5 cm gel rubbing movements are applied to the skin on the affected area 1-3 times a day. For thrombosis of hemorrhoidal veins, pads with applied gel are used.Localized infiltrates and soft tissue swelling.3-5 cm gel rubbing movements are applied to the skin on the affected area 1-3 times a day.Subcutaneous hematomas (including hematomas after phlebectomy).3-5 cm gel rubbing movements are applied to the skin on the affected area 1-3 times a day.Injuries and bruises of joints, tendons, muscle tissue.3-5 cm gel rubbing movements are applied to the skin on the affected area 1-3 times a day. Side effects:Allergic reactions, skin hyperemia. Overdose:Overdose is unlikely due to low absorption of the components of the gel. Interaction:It is not recommended to mix with other agents for external use, do not prescribe locally simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.The combined use of a gel with oral anticoagulants can cause prolonged prothrombin time. Special instructions:It is not recommended for bleeding, if there are local purulent processes, and also applied to open wounds, mucous membranes. Use with extreme caution with increased vascular permeability. The use of the gel is not recommended for deep venous thrombosis. Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions. Form release / dosage:Gel for external use 1000 IU / g. Packaging:For 30 g, 50 g or 100 g in an aluminum tube. Tubu together with instructions for use are placed in a pack of cardboard. Storage conditions:At a temperature not higher than 25 ° C. Keep out of the reach of children. Shelf life:2 years.Do not use after the expiration date printed on the package. Terms of leave from pharmacies:Without recipe Registration number:LP-001895 Date of registration:02.11.2012 The owner of the registration certificate:TATHIMFARMPREPARATY, JSC TATHIMFARMPREPARATY, JSC Russia Manufacturer: & nbspTATHIMFARMPREPARATY, JSC Russia Information update date: & nbsp2016-01-09 Illustrated instructions × Illustrated instructions Instructions