Active substanceSodium HeparinSodium Heparin Similar drugsTo uncover Heparin solution in / in PC ALVILS, LTD. Russia Heparin solution in / in PC BINERGIYA, CJSC Russia Heparin solution in / in PC ELFA NPC, CJSC Russia Heparin gel externally TATHIMFARMPREPARATY, JSC Russia Heparin gel externally MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia Heparin solution in / in PC SLAVYANSKAYA APTEKA, LLC Russia Heparin solution in / in PC BELMEDPREPARATY, RUP Republic of Belarus Heparin solution in / in PC MOSCOW ENDOCRINE FACTORY, FSUE Russia Heparin solution in / in PC MICROGEN FGUP Scientific and Production Association Russia Heparin solution for injections SYNTHESIS, OJSC Russia Heparin solution in / in PC Kursk Biofactory - BIOK, FKP Russia Heparin gel externally GREEN DUBRAVA, CJSC Russia Heparin gel externally Promomed Rus, Open Company Russia Heparin 1000 gel externally ATOLL, LLC Russia Heparin J solution in / in PC JODAS EKSPOIM, LLC Russia Sodium Heparin solution in / in PC ELLARA, LTD. Russia Sodium Heparin solution in / in PC INDUKERN-RUS, OOO Russia Sodium Heparin solution in / in PC FarmSirma Soteks, ZAO Russia Heparin-Akrihin 1000 gel externally AKRIKHIN HFK, JSC Russia Heparin-sodium Brown solution in / in PC B. Brown Mehlungen AG Germany Heparin-Ferein® solution for injections BRYNTSALOV-A, CJSC Russia Lavenum® gel externally POLLO, LLC Russia Lyoton® 1000 gel externally A.Menarini Industry Pharmaceuticals Riunite S.L. Italy Trombles® gel externally NIZHFARM, JSC Russia Thrombogel 1000 gel externally BELMEDPREPARATY, RUP Republic of Belarus Dosage form: & nbspgel for external use Composition:1 g of gel contains:active substance: heparin sodium - 1000 ME (0.00833 g with the activity of heparin sodium 120 IU / mg);Excipients: Ethanol (ethyl alcohol) 0.24 g, methyl parahydroxybenzoate (nipagine, methylparaben) 0.0012 g, propyl parahydroxybenzoate (nipazole, propylparaben) 0.0003 g, diethanolamine (2,2-iminodiethanol) up to 0.014 g to obtain a gel with a pH of 7.5 to 8.7, a carbomer (carbopol) - up to 0.015 g, water (purified water) - up to 1 g. Description:The gel is colorless or with a slight yellowish tint, transparent, with a specific odor. Pharmacotherapeutic group:Anticoagulant direct action for topical application ATX: & nbspB.01.A.B.01 Heparin Pharmacodynamics:Direct anticoagulant, has anti-inflammatory, antiproliferative, anti-edematous and analgesic effect. Reduces platelet aggregation, binds to antithrombin III, preventing the passage of prothrombin in thrombin. Oppresses the activity of thrombin.Reduces the activity of hyaluronidase, increases the fibrinolytic properties of the blood. Trombles® improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and thrombi, eventually restoring the permeability of veins, clinically it is accompanied by a pronounced analgesic and anti-inflammatory effect. Pharmacokinetics:An insignificant amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of heparin in the blood is noted 8 hours after the application. The elimination of heparin, mainly occurs through the kidneys, half-life of 12 hours. Indications:Thrombophlebitis of superficial veins; localized infiltrates and swelling of soft tissues; subcutaneous hematomas (including hematomas after phlebectomy), injuries and bruises of joints, tendons, muscle tissue. Contraindications:Hypersensitivity to the components of the drug; ulcerative-necrotic, purulent processes on the skin; traumatic violation of the integrity of the skin; increased tendency to bleeding, thrombocytopenia. Pregnancy and lactation:It is possible to use the drug during pregnancy and lactation, if the potential benefit to the mother exceeds the risk to the fetus and the baby. Dosing and Administration:Outwardly. The gel column, 3-10 cm long, is lightly rubbed onto the skin over the affected area 1-3 times a day. The gel is used daily, on average from 3 to 7 days. The duration of treatment is determined by the doctor. Side effects:With prolonged use of the drug, local reactions are possible in the form of skin hyperemia, allergic reactions. Overdose:Due to low systemic absorption, an overdose is unlikely. Interaction:The combined use of the gel with indirect anticoagulants can cause lengthening of the isotrobin time.The gel is not prescribed topically at the same time as non-steroidal anti-inflammatory drugs, tetracyclines, antihyetamine drugs. Special instructions:The drug should not be used for bleeding, as well as for open wounds, mucous membranes and purulent processes. Form release / dosage:Gel for external use 1000 IU / g. Packaging:For 10, 20, 30, 40, 50 g in aluminum tubes or in polyethylene laminated tubes.Each tube together with instructions for medical use of the drug is placed in a pack of cardboard. Storage conditions:At a temperature of no higher than 25 ° C.Keep out of the reach of children. Shelf life:3 years. Do not use the drug after the expiration date. Terms of leave from pharmacies:Without recipe Registration number:LS-000112 Date of registration:19.02.2010 / 29.12.2011 The owner of the registration certificate:NIZHFARM, JSC NIZHFARM, JSC Russia Manufacturer: & nbspNIZHFARM, JSC Russia Information update date: & nbsp2016-01-13 Illustrated instructions × Illustrated instructions Instructions