Active substanceSodium HeparinSodium Heparin
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  • Dosage form: & nbspgel for external use
    Composition:

    Per 100 g:

    Active substance: heparin sodium - 100000 ME;

    Excipients: methyl parahydroxybenzoate (nipagine or methylparaben) 0.2 g, ethanol (rectified ethyl alcohol, Extra grade) 24.0 g, carbomer (carbopol) 1.0 g, trolamine (triethanolamine) 0.85 g, lavender essential oil - 0.1 g, purified water - up to 100 g.

    Description:Colorless or yellowish shade gel with a specific odor.
    Pharmacotherapeutic group:Anticoagulant direct action for topical application
    ATX: & nbsp

    B.01.A.B.01   Heparin

    Pharmacodynamics:Anticoagulant of direct action belongs to the group of medium-molecular heparins. With external application, it has a local antithrombotic, anti-exacerbation, moderate anti-inflammatory effect. It blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood.Gradually released from the gel and passing through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots and reducing swelling of tissues.
    Pharmacokinetics:An insignificant amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of heparin in the blood is noted 8 hours after the application. Excretion of heparin, mainly occurs kidney, half-life - 12 hours.
    Indications:

    - Thrombophlebitis of superficial veins;

    - localized infiltrates and swelling of soft tissues;

    - trauma of tendons and joints, bruises of soft tissues and joints;

    - subcutaneous hematomas (including hematomas with closed fractures of the bones of the upper and lower extremities and after phlebectomy in patients with varicose veins).

    Contraindications:Hypersensitivity to the components of the drug, ulcerative necrotic skin changes in places of supposed application of the gel, traumatic violation of the integrity of the skin, low blood coagulability, thrombocytopenia,children's age (medical experience is not available).
    Carefully:With increased permeability of blood vessels.
    Pregnancy and lactation:It is possible to use the drug during pregnancy and during breastfeeding, if the intended benefit for the mother exceeds the potential risk to the fetus.
    Dosing and Administration:

    Outwardly. For all indications, the gel is applied a thin layer on the affected area at the rate of 3-5 cm of gel per skin area 3-5 cm in diameter and gently rubbed into the skin.

    Apply 1-3 times a day daily until the disappearance of inflammatory phenomena, an average of 3 to 7 days. The possibility of a longer treatment is determined by the doctor.

    Side effects:Skin allergic reactions, skin hyperemia.
    Overdose:Overdose is unlikely due to low absorption of the components of the gel.
    Interaction:It is not recommended to mix with other agents for external use, do not prescribe locally simultaneously with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.
    Special instructions:It is not recommended for bleeding, as well as for open wounds,mucous membranes and in the presence of local purulent processes. The use of the gel is not recommended for deep venous thrombosis.
    Effect on the ability to drive transp. cf. and fur:No data.
    Form release / dosage:Gel for external use 1000 IU / g.
    Packaging:

    For 30, 50, 100 g in aluminum tubes or in tubes laminated.

    Each tube with instruction for use is placed in a pack of cardboard.

    Storage conditions:

    In the dark place at a temperature of no higher than 25 ° C.

    Keep out of the reach of children.

    Shelf life:5 years. Do not use after the expiration date.
    Terms of leave from pharmacies:Without recipe
    Registration number:LSR-003344/07
    Date of registration:23.10.2007 / 10.04.2017
    Expiration Date:Unlimited
    The owner of the registration certificate:POLLO, LLC POLLO, LLC Russia
    Manufacturer: & nbsp
    Information update date: & nbsp08.02.2018
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