Heparin - instructions for use, dose, side effects, contraindications

Excipients: carbomer - 15.0 mg; trolamine - 18.0 mg; methylpara-hydroxybenzoate -1.2 mg; propyl parahydroxybenzoate 0.3 mg; lavender oil -1.0 mg; orange flower flowers - 0.5 mg; purified water - up to 1.0 g.

Description:Transparent or opalescent gel, colorless or colorless with a yellowish tinge, with a specific odor. Air bubbles are allowed.

Pharmacotherapeutic group:Anticoagulants direct (heparin and its derivatives)

ATX: & nbsp

B.01.A.B.01 Heparin

Pharmacodynamics:

Anticoagulant of direct action belongs to the group of medium-molecular heparins. With external application, it has a local antithrombotic, anti-exacerbation, moderate anti-inflammatory effect.

It blocks the formation of thrombin, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood. Gradually released from the gel and passing through the skin, heparin reduces the inflammatory process and has an antithrombotic effect, improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas, blood clots and reducing swelling of tissues.

Pharmacokinetics:Absorbed slightly from the surface of the skin. The connection with plasma proteins is up to 95%, the volume of distribution is 0.06 l / kg. It does not penetrate the placenta and into breast milk. Intensively captured by endothelial cells and cells of a mononuclear macromagal system, concentrated in the liver and spleen. Metabolised in the liver with the participation of N-desulfomidase and heparinase of platelets, which is involved in the metabolism of heparin at later stages. Desulfated molecules under the influence of kidney endoglycosidase are converted into low-molecular fragments. The half-life period (T1 / 2) is 1-6 hours (on average - 1.5 hours); increases with obesity, hepatic and / or renal insufficiency; decreases with thromboembolism of the pulmonary artery, infections,malignant tumors. It is excreted by the kidneys, mainly in the form of inactive metabolites. It is not excreted by hemodialysis.

Indications:Thrombophlebitis of superficial veins; localized infiltrates and swelling of soft tissues; subcutaneous hematomas (including hematomas after phlebectomy), injuries and bruises of joints, tendons, muscle tissue.

Contraindications:Hypersensitivity, ulcer-necrotic processes, traumatic violation of the integrity of the skin, thrombocytopenia, increased tendency to bleeding, limiting the use of the drug in children.

Pregnancy and lactation:Data on the use of the drug during pregnancy and lactation are not available.

Dosing and Administration:Outer: a column of gel 3-10 cm long (0.5-1 g) is applied to the affected area (3-5 cm in diameter) 1-3 times a day, daily, until the inflammation disappears, on average, from 3 to 7 days . The possibility of a longer treatment is determined by the doctor.

Side effects:Hyperemia of the skin, allergic reactions.

Overdose:

Due to low systemic absorption, an overdose is unlikely.To date, the phenomenon of overdose with the use of heparin is not described.

With prolonged use on large surfaces, hemorrhagic complications are possible.

Interaction:Do not prescribe locally with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines.

Special instructions:

Do not apply to open wounds, mucous membranes, if there are purulent processes. The use of the gel is not recommended for deep venous thrombosis.

Due to limited experience in the use of the drug should not be used in children.

Effect on the ability to drive transp. cf. and fur:The drug does not affect the ability to drive vehicles and work with other mechanisms.

Form release / dosage:Gel for external use 1000 U / g in aluminum tubes for 15g, 20g, 30g.

Packaging:Each tube together with the instruction for the use of the drug is placed in a pack of cardboard.

Storage conditions:In a dry place at a temperature of 15 to 25 ° C. Keep out of the reach of children.

Shelf life:2 years. Do not use after expiry date.

Terms of leave from pharmacies:Without recipe

Registration number:LP-001441

Date of registration:18.01.2012 / 26.04.2016

Expiration Date:18.01.2017

The owner of the registration certificate:MUROMSKY INSTRUMENT-MAKING PLANT, OJSC MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Manufacturer: & nbsp

MUROMSKY INSTRUMENT-MAKING PLANT, OJSC Russia

Information update date: & nbsp24.03.2017

Illustrated instructions

Instructions

Heparin (Heparin)