Lyoton 1000 - instructions for use, dose, side effects, contraindications

Excipients: Carbomer 940 1.25 g, methyl parahydroxybenzoate 0.12 g, propyl parahydroxybenzoate 0.03 g, ethanol 96% 30.00 ml, neroli oil 0.05 g, lavender oil 0.05 g, trolamine (triethanolamine ) - 0.85 g, purified water - up to 100.00 g.

Description:Colorless or slightly yellowish tinge, almost transparent viscous gel with a pleasant odor.

Pharmacotherapeutic group:Anticoagulant direct action for topical application

ATX: & nbsp

B.01.A.B.01 Heparin

Pharmacodynamics:

Heparin sodium - an anticoagulant of direct action, belongs to the group of medium-molecular heparins. Prevents thrombosis, inhibits the activity of hyaluronidase, activates the fibrinolytic properties of the blood.

With external application has a local antithrombotic, anti-edematous and anti-inflammatory effect,improves microcirculation of blood and activates tissue metabolism, as a result of which the processes of resorption are accelerated; hematomas, the formation of thrombi is prevented, the swelling of the tissues is reduced.

Pharmacokinetics:With external application, a small amount of heparin penetrates into the systemic blood stream, without having a systemic effect, without causing any changes in blood coagulation parameters. Does not penetrate the placental barrier.

Indications:

- Diseases of superficial veins: varicose veins, chronic venous insufficiency and associated complications (thrombophlebitis, periphlebitis);

- Dull injuries and bruises of soft tissues;

- subcutaneous hematomas, including hematomas after operations on veins, phlebectomy;

- localized infiltrates and swelling of soft tissues.

Contraindications:

- Hypersensitivity to the components of the drug;

- violation of the integrity of the skin at the site of application (open wounds, ulcerative necrotic lesions);

- increased tendency to bleeding, thrombocytopenia;

- age to 18 years (safety and efficacy of the drug have not been studied).

Pregnancy and lactation:

The use of the preparation Lyoton 1000 is not contraindicated in pregnancy and during breastfeeding.

Heparin does not penetrate the placental barrier and into breast milk. Due to the insignificant absorption of heparin during external application, the drug does not have a systemic effect on the body. However, before using Lioton® 1000, you should consult your doctor.

Dosing and Administration:

For external use.

A small amount of gel (3-10 cm) 1-3 times a day is applied a thin layer on the skin and gently rubbed.

With localized consequences of injuries and bruises (hematoma, infiltration, soft tissue edema), apply until the symptoms disappear.

With initial symptoms of venous insufficiency ("heaviness", pain in the legs, venous edema) apply for 1 to 3 weeks, depending on the severity of the symptoms.

In chronic venous insufficiency (varicose veins, superficial periphlebitis, superficial thrombophlebitis) apply for 4 to 6 weeks, depending on the severity of the symptoms of the disease.

The need for further treatment is determined by the doctor.

Side effects:In some cases, there may be hypersensitivity reactions to the components of the drug, which are manifested by reddening and / or itching of the skin, which, as a rule, pass after the drug is discontinued.

Overdose:

Very low systemic absorption of the active ingredient of the drug when applied externally makes practically impossible overdose.

In case of an overdose, the action of heparin can be neutralized with a solution of protamine sulfate.

Interaction:It is not recommended to use simultaneously with topical preparations containing tetracyclines, antihistamines or non-steroidal anti-inflammatory drugs.

Special instructions:

It is not recommended to apply to mucous membranes, open wounds and apply in the presence of purulent lesions in the intended place of application of the gel.

With prolonged use of the preparation Lyoton 1000 on large areas of the skin and simultaneous application of anticoagulants of indirect action (warfarin, syncumar, etc.), prothrombin time and coagulation time should be monitored.

It is not recommended to use the preparation Lyoton® 1000 for deep vein thrombosis.

Effect on the ability to drive transp. cf. and fur:Lyoton® 1000 does not affect the ability to drive vehicles and work requiring increased concentration of attention.

Form release / dosage:Gel for external use, 1000 IU / g.

Packaging:

For 30 g, 50 g or 100 g of the drug in aluminum tubes, coated internally with epoxy resin, with a screw cap - perforator (polyethylene / polypropylene).

1 tube with instructions for use in a cardboard pack.

Storage conditions:

At a temperature of no higher than 25 ° C.

Keep out of the reach of children!

Shelf life:

5 years.

Do not use after the expiry date of the product indicated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N012107 / 01

Date of registration:16.09.2011 / 12.08.2014

Expiration Date:Unlimited

The owner of the registration certificate:A.Menarini Industry Pharmaceuticals Riunite S.L.A.Menarini Industry Pharmaceuticals Riunite S.L. Italy

Manufacturer: & nbsp

A.MENARINI Manufacturing Logistics and Servicer Italy

Representation: & nbspBERLIN-CHEMI / MENARINI PHARMA GmbH BERLIN-CHEMI / MENARINI PHARMA GmbH Germany

Information update date: & nbsp10.04.2018

Illustrated instructions

Instructions

Lyoton® 1000 (Lioton® 1000)