Heparin - instructions for use, dose, side effects, contraindications

Excipients: methylparahydroxybenzoate (nipagin) 0.15 g, Ethanol 96% (rectified ethyl alcohol) - 24.0 g, carbomer (Arepol, polyacrylate, Rare cross-linked) - 1.25 g, triethanolamine pure - 0.85 g, lavender oil - 0.02 g, orange flower oil (neroli oil) - 0,01 g, purified water - up to 100,0 in

Description:Transparent or almost transparent, colorless or slightly yellowish shade gel with a specific odor. Opalescence is allowed.

Pharmacotherapeutic group:Anticoagulant direct action for topical application

ATX: & nbsp

B.01.A.B.01 Heparin

Pharmacodynamics:

Direct anticoagulant, has anti-inflammatory, antiproliferative, decongestant and analgesic action. Reduces aggregation of thrombocytes, binds to antithrombin III, preventing the transition prothrombin in thrombin. Oppresses the activity of thrombin. Reduces activity hyaluronidase, increases the fibrinolytic properties of the blood. Gel improves microcirculation and activates tissue metabolism, thereby accelerating the processes of resorption of hematomas and blood clots, ultimately restoring the patency of the veins.

Pharmacokinetics:

An insignificant amount of heparin is absorbed from the surface of the skin into the systemic circulation. The maximum concentration of the drug in the blood is noted 8 hours after the application. The elimination of heparin, mainly occurs through the kidneys, half-life of 12 hours. Does not penetrate the placental barrier.

Indications:

Thrombophlebitis of superficial veins; localized infiltrates and swelling of soft tissues; subcutaneous hematomas (including hematomas after phlebectomy); injuries and bruises of joints, tendons, muscle tissue.

Contraindications:

Hypersensitivity to the components of the drug; ulcerative necrotic changes of the skin in places of supposed application of gel; traumatic violation of the integrity of the skin; thrombocytopenia; increased tendency to bleeding; age to 18 years (safety and efficacy of the drug not studied).

Pregnancy and lactation:

Use of the drug Heparin is not contraindicated in pregnancy and during breastfeeding in the event that the intended benefit to the mother exceeds the potential risk to the fetus. Sodium Heparin does not penetrate the placental barrier and into breast milk. Due to the insignificant absorption of heparin during external application, the drug does not have systemic effects on the body. However, before using the drug, you should consult your doctor.

Dosing and Administration:

Outwardly. Column gel 3-10 cm is applied a thin layer on the affected area and gently rubbed. Apply 1-3 times a day daily until the disappearance of inflammatory phenomena, an average of 3 to 7 days. If there is no improvement after treatment, or the symptoms worsen, or new symptoms appear, it is necessary to consult a doctor. Use the drug only according to the indications, the method of administration and the doses indicated in the instructions.

Side effects:

In some cases, hypersensitivity reactions to components drug, manifested by reddening of the skin and / or skin itching, which, like usually pass after discontinuation of the drug. The drug Heparin can cause allergic reactions (possibly, delayed type) due to the presence of methyl parahydroxybenzoate in the composition.

If any of the side effects listed in the manual are aggravated, or if you notice any other side effects not listed in the instructions, tell your doctor.

Overdose:

Due to low systemic absorption, an overdose is unlikely.

In case of an overdose, consult a doctor immediately.

The action of heparin can be neutralized with a solution of protamine sulfate.

Interaction:

It is not recommended to mix with other products for external use. Do not prescribe topically at the same time with non-steroidal anti-inflammatory drugs, tetracyclines, antihistamines. The combined use of a gel with oral anticoagulants can cause prolonged prothrombin time.

If you use the above or other medicines (including OTC drugs) before using Heparin, consult your doctor.

Special instructions:

It is not recommended for bleeding, if there are local purulent processes, and also applied to open wounds, mucous membranes.

Use with extreme caution in cases of increased permeability of blood vessels. The use of the gel is not recommended for deep venous thrombosis.

Do not exceed the maximum periods and recommended doses of the drug when used alone.

If there is no reduction or if the symptoms of the disease worsen, you should consult a doctor.

With prolonged use of the drug on large areas of the skin and simultaneous use of anticoagulants of indirect action (warfrin, acenocoumarol and others), prothrombin time and clotting time should be monitored. "

The experience of using the drug in children under the age of 18 is absent.

Effect on the ability to drive transp. cf. and fur:

The drug does not affect the ability to drive vehicles and engage in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Form release / dosage:Gel for external use 1000 IU / g.

Packaging:

Gel for external use 1000 IU / g in aluminum tubes with buds of 30.0 g or 50.0 g. Each tube, together with the instruction for use, is placed in a cardboard package.

Storage conditions:

At a temperature of 8 to 25 ° C.

Keep out of the reach of children.

Shelf life:

3 years. Do not use after the expiration date stated on the package.

Terms of leave from pharmacies:On prescription

Registration number:LP-004395

Date of registration:01.08.2017

Expiration Date:01.08.2022

The owner of the registration certificate:GREEN DUBRAVA, CJSC GREEN DUBRAVA, CJSC Russia

Manufacturer: & nbsp

GREEN DUBRAVA, CJSC Russia

Information update date: & nbsp12.09.2017

Illustrated instructions

Instructions

Heparin (Heparin)