Ginkgo Biloba - instructions for use, dose, side effects, contraindications

Active substance: ginkgo biloba leaves the extract is dry with no maintenance less than 24% of flavonoid glycosides and not less than 6% of terpene lactones - 40.0 mg.

Excipients: lactose monohydrate 95.0 mg, croscarmellose sodium - 7.5 mg, silicon dioxide colloidal - 3.0 mg, talc - 3.0 mg, magnesium stearate - 1.5 mg.

Capsules, hard gelatin: titanium dioxide 2.0%, iron oxide yellow (iron oxide) - 0.6286%, gelatin - up to 100%.

Dosage of 80 mg

Active substance: ginkgo bilobate leaf extract is dry with a content of not less than 24% of flavonoid glycosides and at least 6% of terpenic lactones - 80.0 mg.

Excipients: lactose monohydrate - 190.0 mg, croscarmellose sodium - 15.0 mg, silicon dioxide colloid - 6.0 mg, talc - 6.0 mg, magnesium stearate - 3.0 mg.

Capsules hard gelatinous: titanium dioxide - 2,0%, iron oxide yellow (iron oxide) - 0,6286%, gelatin - up to 100%.

Description:

Hard gelatin capsules No. 3 (dosage 40 mg) and No. 0 (dosage 80 mg) are yellow. Contents of the capsules are a powder or compacted mass of a yellowish brown color with particles of brown and white color, disintegrating when pressed.

Pharmacotherapeutic group:angioprotective agent of plant origin.

ATX: & nbsp

N.06.D.X.02 Ginkgo Biloba Leaf Extract

Pharmacodynamics:

The preparation is of plant origin. Increases the body's resistance to hypoxia, especially brain tissue, inhibits the development of traumatic or toxic edema of the brain, improves cerebral and peripheral blood circulation, improves blood rheology.

Has a dose-dependent regulatory effect on the vascular wall, dilates the small arteries, increases the tone of the veins. Prevents formation of free radicals and peroxide oxidation of cell membrane lipids. Normalizes the release, reabsorption and catabolism of neurotransmitters (norepinephrine, dopamine, acetylcholine) and their ability to combine with receptors. It improves the metabolism in organs and tissues, promotes the accumulation of macroerges in cells, increases utilization of oxygen and glucose, normalization of mediator processes in the central nervous system.

Pharmacokinetics:

After ingestion of the ginkgo extract, the ternalactones (ginkgolide A, ginkgolide B and bilobalide) have a high bioavailability, which is 100% (98%) for ginkgolide A, 93% (79%) for ginkgolide B and 72% for bilobalide. After taking 80 mg of extract, the maximum plasma concentrations are: 15 ng / ml for ginkgolide A, 4 ng / ml for ginkgolide B and about 12 ng / ml for bilobalide. The half-life is 3.9 hours (ginkgolide A), 7 hours (ginkgolide B) and 3.2 hours (bilobalide). Binding to blood plasma proteins is: 43% for ginkgolide A, 47% for ginkgolide B and 67% for bilobalide.

Indications:

Dyscirculatory encephalopathy of various etiologies (developing as a result of stroke, craniocerebral trauma, in old age), accompanied by: decreased attention, weakened memory, decreased intellectual abilities, sleep disturbance; peripheral blood circulation and microcirculation (including arteriopathy of the lower limbs), Raynaud's syndrome; neurosensory disorders (dizziness, tinnitus, hypoacusia), senile macular degeneration, diabetic retinopathy.

Contraindications:

increased sensitivity to the components of the drug;
decreased blood clotting;
acute disorders of cerebral circulation;
acute myocardial infarction;
Stomach ulcer and duodenum in the stage exacerbations;
erosive gastritis;
arterial hypotension;
pregnancy, the period of breastfeeding;
age to 18 years;
deficiency of sugar, isomaltase, fructose intolerance, glucose galactose malabsorption.

Dosing and Administration:

Inside, squeezed a small amount water, regardless of food intake.

The duration of treatment is not less than 3 months (especially for patients old age). Conducting re-treatment is possible on the advice of a doctor.

If the doctor is not assigned a different regimen dosing should be followed the following recommendations for admission preparation:

Encephalopathy different etiology:

The dosage of 40 mg

1-2 capsules 3 times a day.

Dosage of 80 mg

1 capsule 2 times a day.

Peripheral blood disorderscirculation and microcirculation (incl. arteriopathy of the lower limbs), Raynaud's syndrome:

The dosage of 40 mg

1 capsule 3 times a day or 2 capsules 2 times a day.

Dosage of 80 mg

1 capsule 2 times a day.

Sensory neurotransmission (dizzinesstinnitus, hypoacusia), senile macular degeneration, diabetic retinopathy:

The dosage of 40 mg

1 capsule 3 times a day or 2 capsules 2 times a day.

Dosage of 80 mg

1 capsule 2 times a day.

If the drug was missed or if an insufficient amount was taken, follow-up should be done as described in this manual without any changes.

Side effects:

Allergic reactions are possible (redness, swelling of the skin, itching), gastrointestinal disturbances (nausea, vomiting, diarrhea), headache, hearing impairment, insomnia, dizziness, decreased blood clotting.

In case of occurrence of any undesirable phenomena, reception of a preparation should be stopped and address to the attending physician.

Overdose:

Cases of drug overdose have not been registered to date.

Interaction:

It is not recommended to use the drug for patients who constantly take acetylsalicylic acid, anticoagulants (direct and indirect action), as well as drugs that reduce blood clotting.

There are isolated cases of bleeding in patients who simultaneously take funds that reduce blood clotting; the causal connection of these bleedings with the administration of Ginkgo bilabial preparations is not confirmed.

When used with antihypertensive drugs, potentiation of antihypertensive effect is possible.

Special instructions:

Improvement of the condition manifests itself 1 month after the start of treatment.

If there is often a sensation of dizziness and noise in the ears, you should consult a doctor. In case of sudden deterioration or loss of hearing, consult a doctor immediately.

Effect on the ability to drive transp. cf. and fur:

Given the potential for side effects from the central nervous system when taking the drug, caution should be exercised in carrying out potentially dangerous activities requiring an increased concentration of attention and speed of psychomotor reactions (including the management of vehicles, work with moving mechanisms).

Form release / dosage:

Capsules 40 mg and 80 mg.

Packaging:For 10, 15 or 20 capsules in a planar cell pack of a polyvinyl chloride film and aluminum foil.

2, 3, 4 or 6 contiguous cell packs of 10 capsules, or 2, 4 or 6 out-of-round cell packs of 15 capsules, or 1, 2 or 3 cell outlets with 20 capsules together with the instructions for use are placed in a pack of cardboard.

Storage conditions:

In the dark place at a temperature of no higher than 25 ° C.

Keep out of the reach of children.

Shelf life:

2 years. Do not use after expiry date.

Terms of leave from pharmacies:On prescription

Registration number:LP-002183

Date of registration:15.08.2013

The owner of the registration certificate:VERTEKS, AO VERTEKS, AO Russia

Manufacturer: & nbsp

VERTEKS, AO Russia

Representation: & nbspVERTEKS CJSC VERTEKS CJSC Russia

Information update date: & nbsp13.12.2015

Illustrated instructions

Instructions

Ginkgo biloba (Ginkgo biloba)