Included in the formulation
АТХ:N.06.D.X.02 Ginkgo Biloba Leaf Extract
Pharmacodynamics:Ginkgo biloba extract is a herbal preparation. Improves cerebral circulation, normalizing the metabolism in cells and tissues, increases the supply of the brain with oxygen and glucose. It has antihypoxic effect, promotes accumulation of macroerges in cells. Prevents formation of free radicals and peroxide oxidation of cell membrane lipids.Normalizes mediator processes in the central nervous system: promotes the release, re-uptake and catabolism of norepinephrine, dopamine and acetylcholine, their combination with receptors. Improves the rheological properties of blood: reduces the aggregation of erythrocytes, inhibits the factor of platelet activation. Regulates vascular blood filling, stimulating the development of endothelium-dependent relaxing factor, dilates small arteries, increases the tone of veins. Has anti-edematous effect, reducing the permeability of the vascular wall both at the level of the brain and on the periphery. Has antithrombotic effect due to stabilization of platelet membranes and influence on the synthesis of prostaglandins.
Pharmacokinetics:After ingestion, it is well absorbed. It has high bioavailability (72-100%). The maximum concentration in the blood is detected after 1.5 hours, the half-life is between 3.2 and 7 hours. The relationship with plasma proteins is different for different terpenoctoids: 43% for ginkolide A, 47% for ginkolide B, 67% for bilobalide. The drug is low toxicity.
Indications:- Decreased attention, memory loss, decreased intellectual abilities, sleep disturbance (with stroke, brain injury, old age).
- Violation of peripheral circulation and microcirculation (including arteriopathy of the lower limbs), Raynaud's syndrome.
- Neurosensory disorders (dizziness, ringing in the ears, hypoacusia).
- Senile degeneration of the macula, diabetic retinopathy.
V.F00-F09.F07 Personality and behavioral disorders due to illness, damage or dysfunction of the brain
V.F50-F59.F51.2 Sleep and wakefulness disorder inorganic etiology
VIII.H80-H83.H81 Violations of the vestibular function
VIII.H90-H95.H93.0 Degenerative and vascular diseases of the ear
IX.I60-I69.I67.2 Cerebral atherosclerosis
IX.I60-I69.I69 Effects of cerebrovascular disease
XVIII.R40-R46.R42 Dizziness and dizziness
Contraindications:- Hypersensitivity to the drug or its components
- Acute disorders of cerebral circulation
- Acute myocardial infarction
- Arterial hypotension
- Reduced blood clotting
- Stomach ulcer and duodenal ulcer
- Erosive gastritis
- Pregnancy, lactation
- Children under 18 years old
- Deficiency of sugar, isomaltase, fructose intolerance, glucose-galactose malabsorption
Carefully:Hypersensitivity, tendency to bleeding.
Pregnancy and lactation:It is not recommended to use the drug during pregnancy and breastfeeding.
Dosing and Administration:Inside, regardless of the reception prishchi, washing down with water.
Symptomatic treatment of disorders of cerebral circulation: 1-2 capsules (40 mg) 3 times a day or 1 capsule (80 mg) 2 times a day. The course of treatment is 8 weeks.
Violations of peripheral circulation, vascular or involutional pathology: 1 capsule (40 mg) 3 times a day, or 2 capsules (40 mg) 2 times a day, or 1 capsule (80 mg) 2 times a day. The course of treatment is 6-8 weeks.
Side effects:- Allergic reactions (itching, redness, swelling of the skin)
- Gastrointestinal disorders (nausea, vomiting, diarrhea)
- Headache, dizziness
- Hearing impairment
- Reduced blood clotting
Overdose:Cases of drug overdose are not registered. Ginkgo biloba is well tolerated by the body.
Interaction:With the simultaneous use of ginkgo biloba with antihypertensive drugs, potentiation of the antihypertensive effect is possible.
It is not recommended simultaneous use with acetylsalicylic acid,anticoagulants direct and indirect action, drugs that reduce blood clotting.
Special instructions:Treatment is long. Improvement occurs one month after the start of the drug. In case of sudden deterioration of the condition, hearing loss is recommended immediately to see a doctor.