Tanacan® (Tanakan®)

Composition Pharmacodynamics Indications Carefully Contraindications Dosing and Administration Side effects Form release / dosage
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Active substanceGinkgo biloba leaf extractGinkgo biloba leaf extract
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    • Dosage form: & nbsporal solution
    Composition:

    Solution for oral administration 40 mg / ml (composition on 100 ml):

    Active substance: Ginkgo biloba leaf extract (EGb 761®): 24% of flavonol glycosides and 6% of ginkgolides-bilobalides - 4000.00 mg

    Excipients: sodium saccharinate 500.00 mg, orange flavor 0.75 ml, lemon flavor 0.75 mg, ethanol 96% 59.00 ml, purified water 100.00 ml.

    Description:

    The solution is brownish-orange with a characteristic odor.

    Pharmacotherapeutic group:angioprotective agent of plant origin.
    ATX: & nbsp

    N.06.D.X.02   Ginkgo Biloba Leaf Extract

    Pharmacodynamics:
    Standardized and titrated preparation of plant origin, the effect of which is due to the influence on metabolic processes in cells, rheological properties of blood, as well as vasomotor reactions of blood vessels.
    The drug improves the supply of the brain with oxygen and glucose. Normalizes the tone of arteries and veins, improves microcirculation. Helps improve blood flow, prevents the aggregation of red blood cells. Has a retarding effect on the platelet activation factor.
    It improves metabolic processes, has antihypoxic effect on tissues. Prevents formation of free radicals and peroxide oxidation of cell membrane lipids. Affects the release, reverse capture and catabolism of neurotransmitters (norepinephrine, acetylcholine, dopamine, serotonin) and their ability to bind to membrane receptors.
    Pharmacokinetics:Ginkgolides A and B and bilobalides have a bioavailability of 80% to 90% when taken orally. Cmax is achieved in 1-2 hours; T1 / 2 is from 4 hours (ginkgolid A and bilobalid) to 10 h (ginkgolid B). The main way of excretion is the kidneys.
    Indications:

    • cognitive and sensorine deficiency of various genesis (with the exception of Alzheimer's disease and dementia of various etiologies);
    • intermittent claudication in chronic obliterating arteriopathies of the lower extremities (2 degrees Fontaine);
    • impaired vision of vascular genesis, a decrease in its severity;
    • hearing impairment, tinnitus, dizziness and coordination disorders of predominantly vascular genesis;
    • disease and Reynaud's syndrome.

    Contraindications:
    • erosive gastritis in the stage of exacerbation;
    • peptic ulcer of the stomach and duodenum in the stage of exacerbation;
    • acute disorders of cerebral circulation;
    • acute myocardial infarction;
    • decreased blood clotting;
    • Congenital galactosemia, lactase deficiency, lactose intolerance, glucose / galactose malabsorption syndrome (for tablets);
    • children and adolescents under 18;
    • pregnancy;
    • lactation period (breastfeeding);
    • hypersensitivity to any of the components of the drug.
    Carefully:should be administered to patients with alcoholism, liver disease, craniocerebral trauma and brain disease, since the drug in the form of a solution contains 450 mg of ethyl alcohol per 1 dose (1 dose).
    Pregnancy and lactation:Tanakan is contraindicated in pregnancy and lactation (breastfeeding) due to the lack of clinical data on the use of the drug in this group of patients.
    Dosing and Administration:
    Inside adults 1 ml of solution 3 times a day during meals.
    Pre-dissolve in 1/2 cup water, use the supplied pipette dispenser. 1 dose-1 ml of solution.
    The minimum course of treatment is 3-6 months.
    Side effects:

    Allergic reactions: redness, skin rash, swelling, itching, urticaria.

    From the coagulation system of the blood: decreased blood clotting and the possibility of bleeding (with prolonged use).

    Dermatological reactions: eczema.

    From the side of the central nervous system: headache, dizziness, tinnitus.

    From the digestive system: nausea, vomiting, abdominal pain, dyspepsia, diarrhea.

    In case of adverse reactions, the patient should stop taking the drug and consult a doctor.

    Overdose:Cases of drug overdose are unknown.
    Interaction:
    In clinical studies with EGb 761, both inhibition and induction of cytochrome P450 isoenzymes were detected.With the simultaneous administration of EGb 761 with midazolam, the level of the latter changed presumably because of the effect on CYP3A4. Therefore, caution should be exercised in the joint administration of EGb 761 and drugs metabolized by the CYP3A4 isoenzyme and having a low therapeutic index.
    Do not apply the drug to patients who systematically use acetylsalicylic acid (as an antiplatelet agent), anticoagulants (direct and indirect action), and other drugs that reduce blood clotting.
    With the simultaneous use of Tanakan in the form of a solution for oral administration with antibiotics, a group of cephalosporins (cefamandol, cefoperazone, latamoxef), gentamicin, chloramphenicol, disulfiram, thiazide diuretics, anticonvulsants, oral hypoglycemic agents (chlorpropamide, glibenclamide, glipizide, tolbutamide, metformin (possible development of lactic acidosis)), antifungal agents (griseofulvin), derivatives of 5-nitroimidazole (metronidazole, ornidazole, secnidazole, tinidazole), ketoconazole, cytostatics (procarbazine), tricyclic antidepressants, tranquilizers may cause such reactions as hyperthermia, skin flushing, vomiting, heart palpitations, since 1 dose of Tanakan in the form of oral solution contains 450 mg of ethyl alcohol.
    Special instructions:

    Before using the drug, you need to consult a doctor.

    Improvement of the condition manifests itself 1 month after the start of treatment.

    In one single dose of oral solution contains 450 mg of ethyl alcohol (57% v / v), in the maximum daily dose of 1.35 g of ethyl alcohol.


    Effect on the ability to drive transp. cf. and fur:
    During the period of taking the drug, it is not recommended to perform potentially dangerous activities requiring an increased concentration of attention and speed of psychomotor reactions (including control of vehicles, work with moving mechanisms), since the drug may cause dizziness and the solution contains ethyl alcohol.
    Form release / dosage:solution for oral administration 40 mg / ml
    Packaging:To 30 ml in a glass bottle of dark glass with a screw cap. The bottle and pipette-dispenser in a plastic container with a capacity of 1 ml in place with instruction for use are placed in a packcardboard.
    Storage conditions:The drug should be stored out of the reach of children at a temperature of no higher than 25 ° C.
    Shelf life:3 years.
    Terms of leave from pharmacies:Without recipe
    Registration number:П N011709 / 02
    Date of registration:15.08.2011
    The owner of the registration certificate:IPSEN PHARMA IPSEN PHARMA France
    Manufacturer: & nbsp
    Information update date: & nbsp14.12.2015
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