According to the World Health Organization (WHO), undesirable effects are classified according to their frequency of development as follows: very often (≥1/10), often (≥1 / 100, <1/10), infrequently (≥1 / 1000, < 1/100), rarely (≥1 / 10000, <1/1000), very rarely (<10000) the frequency is unknown (the frequency of occurrence of phenomena can not be determined from the available data).
On the part of the hematopoiesis and lymphatic system:
Rarely: hemorrhagic anemia, leukopenia;
Frequency unknown: agranulocytosis, thrombocytopenia, impaired bone marrow function.
From the immune system:
Frequency unknown: anaphylactic reactions (including anaphylactic shock).
From the nervous system:
Infrequently: headache, dizziness, drowsiness;
Rarely: paresthesia;
Frequency unknown: convulsions, a violation of taste.
From the sense organs:
Rarely: blurred vision, tinnitus.
From the side of the cardiovascular system:
Frequency unknown: heart failure, hypertension, vasodilation.
From the respiratory system:
Rarely: asthma, nosebleeds, laryngeal edema;
Frequency unknown: bronchospasm (in particular, in patients with hypersensitivity to NSAIDs), rhinitis.
From the gastrointestinal tract:
Often: nausea, vomiting, indigestion, pain in the abdomen;
Infrequently: constipation, diarrhea, bloating, gastritis;
Rarely: peptic ulcer, stomatitis;
Rarely: exacerbation of ulcerative colitis or Crohn's disease, gastrointestinal bleeding, perforation.
From the liver and biliary tract:
Rarely: hepatitis, an increase in the level of "hepatic" enzymes and bilirubin.
From the skin:
Infrequently: skin rash, itchy skin;
Frequency unknown: photosensitization, alopecia, urticaria, angioedema, erythema, bullous rash, toxic epidermal necrolysis.
From the urinary system:
Rarely: acute renal failure, interstitial nephritis, nephrotic syndrome, abnormal values of renal function indicators.
Other:
Infrequently: swelling, fatigue;
Rarely: increase in body weight.