The undesirable phenomena presented below are listed depending on the anatomical and physiological classification and frequency of occurrence.
The incidence of side effects is defined as follows: very often -> 1/10 assignments (> 10%), often - 1 / 10-1 / 100 assignments (> 1% and <10%), infrequently - 1/100 to 1 / 1000 assignments (> 0.1% and <1%), rare - 1 / 1000-1 / 10000 assignments (> 0.01% and <0.1%), very rare <1/10000 assignments (<0.01 %, including single messages).
From the digestive system: often - NSAID-gastropathy, abdominal pain, dyspepsia (nausea, vomiting, heartburn, flatulence, decreased appetite, diarrhea), infrequently - stomatitis, a violation of liver function; rarely - erosive and ulcerative lesions; very rarely - bleeding and perforation of the gastrointestinal tract, a change in taste.
From the nervous system: often - headache, dizziness, insomnia, agitation, nervousness, drowsiness, depression, asthenia, rarely - confusion or loss of consciousness, forgetfulness, memory impairment, migraine, peripheral neuropathy.
From the sense organs: rarely - noise or ringing in the ears, blurred vision, conjunctivitis, dry eye mucosa, eye pain, conjunctival hyperemia, hearing loss, dizziness, vertigo.
From the side of the cardiovascular system: rarely - swelling, increased blood pressure, rarely - tachycardia.
From the respiratory system: infrequently - hemoptysis, dyspnea, pharyngitis, rhinitis, bronchospasm, laryngeal edema (signs of anaphylactic reaction); rarely - asthma attacks.
On the part of the organs of hematopoiesis: rarely - agranulocytosis, anemia, hemolytic anemia, thrombocytopenia, leukopenia. High doses of ketoprofen can inhibit platelet aggregation, thus prolonging the bleeding time, and cause nasal bleeding and hematoma formation.
From the urinary system: infrequent - edematous syndrome, rarely - cystitis, urethritis, renal dysfunction, interstitial nephritis, nephrotic syndrome, very rarely - hematuria.
From the immune system: infrequently, the reactivity of the respiratory system, including bronchial asthma, exacerbation, bronchospasm, or dyspnea (especially in patients with hypersensitivity to acetylsalicylic acid and other non-steroidal anti-inflammatory drugs); very rarely - angioedema and anaphylaxis.
Allergic reactions: often - skin rash (including erythematous urticaria), itching of the skin, infrequently - rhinitis, rarely exfoliative dermatitis.
Other: infrequent - increased sweating, rarely - epistaxis, myalgia, muscle twitching, shortness of breath, thirst, photosensitivity, with prolonged use in large doses - vaginal bleeding.