From the digestive system: NSAIDs-gastropathy, heartburn, nausea, vomiting, diarrhea, constipation, flatulence, decreased appetite, stomatitis, abdominal pain and epigastric region; rarely - a change in taste. With prolonged use in large doses - ulceration of the mucous membrane of the gastrointestinal tract, gingival, hemorrhoidal bleeding, intestinal perforation.
From the urinary system: rarely - cystitis, urethritis, renal dysfunction, acute renal failure, interstitial nephritis, nephrotic syndrome, hematuria, edema (especially in patients with arterial hypertension).
From the side of the liver: changes in transaminase activity may be noted; rarely - hepatitis.
From the nervous system: agitation, nervousness, drowsiness, depression, asthenia, headache, dizziness, sleep disturbance, insomnia, tinnitus; rarely - confusion or loss of consciousness, forgetfulness, migraine, peripheral neuropathy.
From the side of the cardiovascular system: heart failure, increased blood pressure; rarely - tachycardia.
Hypersensitivity reactions: rhinitis, angioedema, anaphylactic shock, rash, itching, urticaria, asthmatic attack, especially in patients with hypersensitivity to acetylsalicylic acid, as well as to other drugs from the NSAID group.
Skin reactions: photosensitivity, alopecia, polymorphic erythema, multi-form exudative erythema, including Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome).
On the part of the organs of hematopoiesis: anemia, leukopenia, thrombocytopenia, agranulocytosis, pancytopenia; rarely - hemolytic anemia.
From the sense organs: reversible toxic amblyopia,unclear vision or double vision; rarely - conjunctivitis, dry eye mucosa, eye pain, conjunctival hyperemia, decreased hearing.
Other: increased sweating; rarely - hemoptysis, epistaxis, myalgia, muscle twitching, shortness of breath, thirst, with prolonged use in large doses - vaginal bleeding.
If any side effects occur, stop taking the medication immediately.