Intravenously (intravenously) or intramuscularly (in / m).
Adults - 2-4 g / day in equal parts every 12 hours; in case of serious infections, the dose can be increased up to 8 g / day in equal parts every 12 hours.Treatment with the drug can begin before the results of a study of the sensitivity of microorganisms.
With uncomplicated gonococcal urethritis, a one-time intramuscular injection of 500 mg of the drug is recommended.
In the treatment of infections caused by Streptococcus pyogenes, in adults and children, the duration of therapy should be at least 10 days.
Prevention of postoperative complications - 1 g or 2 g of the drug intravenously for 30-90 minutes before the start of the operation, with a repeat every 12 hours (in most cases for no more than 24 hours). In case of operations with an increased risk of infection (for example, surgery in the colorectal area) or if the infection is especially dangerous (for example, in open-heart surgery or joint replacement), the drug can be prevented for 72 hours after the operation is completed.
In case of impaired renal function - 2-4 g / day. For patients with a glomerular filtration rate below 18 ml / min or a creatinine concentration above 3.5 mg / dl, the dose should not exceed 4 g / day.
When hemodialysis, the half-life of cefoperazone from the blood serum decreases slightly, so the drug should be administered after the end of dialysis.
With severe violations of the liver, severe obstruction of the biliary tract The daily dose of the drug should not exceed 2 g.
In patients with renal-hepatic insufficiency, the concentration cefoperazone in the blood and, if necessary, adjust the dose. Detyam - 50-200 mg / kg body weight / day in equal parts every 8-12 hours. The maximum daily dose is 12 g. At intravenous jet slow introduction the maximum single dose makes 50 mg / kg, duration of introduction - not less than 3-5 minutes. Newborn (<8 days) - 50-200 mg / kg body weight / day in equal parts every 12 hours. The drug is injected deep in the / m into the large gluteus muscle or to the front surface of the thigh. For IV injection, the maximum single dose is 2 g; duration of administration - at least 3-5 minutes. Duration iv in the drip introduction is 15-60 min. DThe oases and duration of treatment are determined by the nature and severity of the infection and are set individually.
Preparation of solutions
Intramuscular injection
For the introduction, it is recommended to dilute the preparation in two stages: 1) first, the necessary amount of sterile water for injections is added to the contents of the vial (see table) and shaken vigorously until the powder is completely dissolved.The prepared solution is maintained until the small air bubbles formed during the dissolution process disappear; 2) the required amount of 2% lidocaine solution is added to the resulting solution and mixed.
| Contents in the vial | 1 stage Sterile water volume | Stage 2 The volume of a 2% solution of lidocaine | The final volume | Concentration solution of cefoperazone |
| 1 g | 2.8 ml | 1.0 ml | 4.0 ml | 250 mg / ml |
| 2 grams | 5.4 ml | 1.8 ml | 8.0 ml | 250 mg / ml |
Intravenous administration
To prepare a solution for intravenous administration, 5 ml of solvent per g of cefoperazone are used. The contents of the vial are dissolved in any of the following compatible solutions: 5% or 10% dextrose injection, 5% dextrose injection and 0.9% or 0.2% sodium chloride solution for injection, 0.9% sodium chloride solution for injections, Ringer's lactate solution, sterile water for injection. The solution is thoroughly mixed and the entire amount of the resulting solution is diluted with one of the above (except water) solvents for intravenous administration.
The prepared solution can be used both in the form of continuous infusion, and in the form of intermittent administration.
Continuous infusion - the stock solution is diluted to a solution with a concentration of 2-25 mg / ml cefoperazone.
Intermittent infusion - the contents of one bottle are dissolved in 20-40 ml of a compatible sterile solution for intravenous administration and injected for 15-30 minutes. In accordance with the requirements of good clinical practice, only freshly prepared solutions are recommended, but the solution remains stable when stored for 24 hours at room temperature and for 120 hours when stored in a refrigerator (2-8 ° C).