Cefoperazone is administered intravenously (by drip and jet) and intramuscularly.
Adults: average daily dose of 2-4 g of cefoperazone, administered in equal portions every 12 hours. In severe infections, the daily dose may be increased to 8 grams, also administered in equal portions every 12 hours. There was no evidence of any complications cefoperazone when administered at a daily dose of 12 g and even 16 g divided into equal doses every 8 hours. Treatment can be started before the results of a study of the sensitivity of microorganisms.
With uncomplicated gonococcal urethritis, a one-time intramuscular injection of 500 mg of the drug is recommended.
For the prevention of postoperative complications - 1 g or 2 g IV for 30-90 min before the operation. The dose can be repeated every 12 hours, however, in most cases within no more than 24 hours.
In cases of operations with an increased risk of infection (for example, colorectal area), or if the infection is particularly dangerous (for example, in open-heart surgery or joint prosthetics), prophylactic use can continue for 72 hours after the operation is completed.
Patients with impaired renal function are given a usual daily dose (2-4 g). Patients who have a glomerular filtration rate below 18 ml / min or serum creatinine above 3.5 mg / ml, daily dose should not exceed 4 g.
In patients with severe impairment of liver function, expressed by obstruction of the bile ducts, the daily dose of the drug should not exceed 2 g.
In patients with renal-hepatic insufficiency, the concentration of cefoperazone in the blood should be monitored and, if necessary, the dose should be adjusted.
Use in children
In children, the daily dose of cefoperazone is 50-200 mg / kg body weight, administered in equal portions in two divided doses every 12 hours or more if necessary. The maximum daily dose is 12 g.
For IV injections, the maximum single dose for children is 50 mg / kg, the duration of administration is at least 3-5 minutes. Newborn (<8 days) is administered a 50- 200 mg / kg body weight per day in equal parts every 12 hours. Daily doses up to
up to 300 mg / kg were used without complications in young children and children with severe infections, including bacterial meningitis.
Intravenous administration
As a solvent, 5% dextrose solution, isotonic sodium chloride solution (0.9%), sterile water for injection can be used.
To prepare a solution for intravenous administration, 1 g of cefoperazone should be dissolved in 10 ml of sterile water for injection or another compatible solution and administered for a minimum of 3-5 minutes. For intravenous administration, the maximum single dose of cefoperazone for adults is 2 g, for children - 50 mg / kg body weight. When preparing the solution for intravenous drip, 1 g of cefoperazone is dissolved in 5 ml of sterile water for injection, the resulting solution is added to the infusion solution (Ringer's lactate solution, 5% dextrose solution,isotonic sodium chloride solution) to a concentration of 20-100 mg / ml. The duration of administration depending on the volume of the solution can be from 10-30 minutes or more.
Intramuscular injection
For the preparation of solutions intended for w / o Injection, may be used sterile water for injections or isotonic sodium chloride solution. To dilute 0.5 g of the drug should be used 2 ml of solvent, 1 g - 4 ml to obtain a final concentration of cefoperazone 250 mg / ml. To reduce pain with intramuscular injections, when a solution with a concentration of 250 mg / ml and more is intended to be administered, a solution of lidocaine is recommended to prepare the solution (in case the patient does not have a hypersensitivity reaction to lidocaine). This solution can be prepared using sterile water for injection in combination with a 2% solution of lidocaine. The following two-step dilution method is recommended: first add the required amount of sterile water for injection and shake until cefoperazone powder completely dissolves,then add the required amount of 2% lidocaine and mix.
| | The final concentration of cefoperazone | Stage 1 Sterile water volume | 2 stage Volume of 2% lidocaine |
| Bottle 1 g | 250 mg / ml | 2.6 ml | 0.9 ml |
| Bottle 1 g | 333 mg / ml | 1.8 ml | 0.6 ml |
In / m injection is made deep into the large muscle (the gluteus maximus muscle or the anterior surface of the thigh).