Intravenous (drip, jet), intramuscularly.
Adults: an average daily dose of cefoperazone 2- 4 g, administered in equal parts every 12 hours. In severe infections, the daily dose can be increased to 8 g, administered also in equal parts every 12 hours. There were no complications in the administration of cefoperazone in the daily dose of 12 g and even 16 g divided into equal doses every 8 h. Treatment can be initiated before the results of a study of the sensitivity of microorganisms.
With uncomplicated gonococcal urethritis, a one-time intramuscular injection of 500 mg of the drug is recommended.
For the prevention of postoperative complications - 1 g or 2 g IV for 30-90 min before the operation. The dose can be repeated every 12 hours, however, in most cases for no more than 24 hours.
In case of operations with an increased risk of infection (for example, operations in the rectal area), or if the infection is especially dangerous (for example, in open-heart surgery or joint replacement), preventive use can continue for 72 hours after the operation is completed. Patients with impaired renal function are given a usual daily dose (2-4 g). Patients who have a glomerular filtration rate below 18 ml / min or a serum creatinine level above 3.5 mg / dL should not exceed a daily dose of 4 g.
In patients with severe impairment of liver function, expressed by obstruction of the bile ducts, the daily dose of the drug should not exceed 2 g. In patients with renal-hepatic insufficiency, the concentration of cefoperazone in the blood should be monitored and, if necessary, the dose should be adjusted.
Use in children
In children, the daily dose of cefoperazone is 50-200 mg / kg body weight, administered in equal portions in two divided doses (every 12 hours) or more if necessary. The maximum daily dose is 12 g.
For IV injections, the maximum single dose for children is 50 mg / kg, the duration of administration is at least 3-5 minutes.Newborns (<8 days) receive 50-200 mg / kg of body weight per day in equal parts every 12 hours. Daily doses up to 300 mg / kg were applied without complications in young children and children with severe infections, including bacterial meningitis. Efficacy and safety of use in children has not been established to date.
Intravenous administration
A solution for intravenous administration is prepared ex tempore.
As a solvent, -5% dextrose solution, 10% dextrose solution, 0.9% sodium chloride solution, sterile water for injection can be used. To prepare a solution for intravenous administration, 1 g of cefoperazone should be dissolved in 10 ml of sterile water for injection or another compatible solution and administered for a minimum of 3-5 minutes. For intravenous administration, the maximum single dose of cefoperazone for adults is 2 g, for children - 50 mg / kg body weight.
When preparing the solution for intravenous administration of droplets to facilitate dissolution, it is recommended to use 5 ml of solvent per 1 g of cefoperazone. The resulting solution is added to the infusion solution (Ringer's lactate solution, 5% dextrose solution, 0.9% sodium chloride solution) in a volume of 20-100 ml. The duration of administration depending on the volume of the solution can be from 10-30 minutes or more.
Intramuscular injection
For the preparation of solutions intended for intravenous injections, sterile water for injection or 0.9% solution of sodium chloride. To dilute 0.5 g of the drug should be used 2 ml of solvent, 1 g - 4 ml to obtain a final concentration of cefoperazone 250 mg / ml. To reduce pain with intramuscular injections, when a solution with a concentration of 250 mg / ml and more is intended to be administered, it is recommended to use a 2% lidocaine solution to prepare the solution (in case the patient has no hypersensitivity reaction to lidocaine). This solution can be prepared using sterile water for injection in combination with a 2% solution of lidocaine. The following two-step dilution method is recommended: first add the required amount of sterile water for injection and shake until cefoperazone powder completely dissolves, then add the necessary amount of 2% lidocaine and mix.
| | The final concentration of cefoperazone | Stage 1 Sterile water volume | 2 stage Volume of 2% lidocaine |
| Bottle 1 g | 250 mg / ml | 2.6 ml | 0.9 ml |
| Bottle 1 g | 333 mg / ml | 1.8 ml | 0.6 ml |
In / m injection is made deep into the large muscle (the gluteus maximus muscle or the anterior surface of the thigh).