Intravenous, intramuscular.
Doses and duration of treatment are determined by the nature and severity of the course: infections and are set individually. It is recommended to monitor the concentration of cefoperazone in the blood serum (assuming that the daily dose is more than 2 g) with a combined disturbance of liver and kidney function and, if necessary, adjust the dose.
Adults - in an average daily dose of 2 - 4 g, divided into 2 doses. In severe infections, the daily dose can be increased to 12 g and administered 2 to 4 g every 8 hours or 3 to 6 g every 12 h. Treatment with the drug can be started before the results of a study of the sensitivity of microorganisms.
With uncomplicated gonococcal urethritis, a single intramuscular injection of 0.5 g of the drug is recommended.
In the treatment of infections caused by Streptococcus pyogenes in adults and children, the duration of therapy should be at least 10 days.
For the prevention of postoperative complications - intravenously for 1 g or 2 g for 30-90 min before the operation. The dose can be repeated every 12 hours (in most cases for no more than 24 hours). For operations with an increased risk of infection (for example, operations in the colorectal area) or if the infection is dangerous (for example, in open-heart surgery or joint replacement), the prophylactic use of the drug may continue for 72 hours after the operation is completed.
Because the cefoperazone is mainly excreted not through the kidneys, when applied in therapeutic doses (2-4 g / day) in patients with impaired renal function, dose adjustment is not required. Patients who have a glomerular filtration rate below 18 ml / min or a serum creatinine level above 3.5 mg / dL should not exceed a daily dose of 4 g.
When hemodialysis, the half-life of cefoperazone from the blood serum decreases slightly, so the drug should be administered after the end of dialysis.
Children the drug should be given in daily doses at a rate of 50 to 200 mg / kg of body weight; the drug should be injected every 8-12 h. The maximum daily dose is 12 g.
Newborns (less than 8 days) - daily dose is 50-200 mg / kg body weight; the drug should be injected every 12 hours.
Daily doses up to 300 mg / kg were applied without complications in children "of early age and children with severe infections, including bacterial meningitis.
Preparation of solutions for injection:
For intramuscular injection - To 1.0 g of cefoperazone 4.0 ml of solvent is added to obtain a final concentration of cefoperazone 250 mg / ml. The following solutions can be used as solvents:
- water for injections;
- 0.9% solution of sodium chloride.
To reduce the pain with intramuscular injections in cases where a solution with a concentration of 250 mg / ml or more is supposed to be introduced, it is recommended to use a solution 2% lidocaine solution (in case the patient does not have a hypersensitivity reaction to lidocaine).This solution can be prepared using water for injection in combination with 2% lidocaine solution.
The following two-step dilution method is recommended: first add the required amount of water for injections and shake until cefoperazone powder completely dissolves, then add the necessary amount of 2% lidocaine solution and mix.
| | The final concentration of cefoperazone | Stage 1 The volume of water for injection | 2 stage Volume of 2% lidocaine solution |
| Bottle of 1.0 g | 250 mg / ml | 2.6 ml | 0.9 ml |
| Bottle of 1.0 g | 333 mg / ml | 1.8 ml | 0.6 ml |
Intramuscular injection is done deep into the large muscle (the gluteus maximus muscle or the anterior thigh surface).
For intravenous fluid administration - 1.0 g of the preparation is dissolved in 10 ml of solvent. The following solutions can be used as solvents:
- water for injections;
- 0.9% solution of sodium chloride;
- 5% dextrose solution;
With intravenous jet injection, the maximum single dose of the drug for adults is 2.0 g, for children - 50 mg / kg body weight. The duration of administration is at least 3-5 minutes.
For intravenous drip - 1.0 g of the drug is dissolved in 5 ml of water for injection. The resulting solution is added to 20-100 ml of an infusion solution (0.9% sodium chloride solution, 5% dextrose solution, Ringer's lactate solution).
The duration of intravenous drip introduction, depending on the volume of the solution can be from 10-30 minutes or more.
When used as a solvent for sterile water for injection, its volume should not exceed 20 ml.