Intravenous and intramuscular.
Adults - in an average daily dose of 2000-4000 mg, 2 times a day. In severe infections, the dose can be increased to 12000 mg / day: 2000-4000 mg every 8 hours, or 3000-6000 mg every 12 hours. Treatment can be started before receiving the results of the sensitivity study of microorganisms. With uncomplicated gonococcal urethritis - once, intramuscularly, 500 mg.
For antibacterial prophylaxis of postoperative complications-IV, 1000 mg or 2000 mg 30-60 minutes before the beginning of the operation, with repeated every 12 hours (in most cases within 24 hours). In case of operations with an increased risk of infection (for example, operations in the colorectal area), or if the infection can be particularly harmful (for example, in open-heart surgery or joint prosthetics), the prophylactic use of the drug may continue for 72 hours after the operation is completed.
In patients with renal-hepatic insufficiency - not more than 2000 mg / day. Patients with a glomerular filtration rate below 18 ml / min, or creatinine above 3.5 mg / ml - not more than 4000 mg / day. With isolated liver failure, no dose reduction is required if the patient does not receive the maximum dose, compensatory increases in renal excretion of the drug to 90% or more.
Children - daily doses from 50 to 200 mg per 1 kg of body weight; in 2 admission (every 12 hours) or more, if necessary. Newborns (less than 8 days), every 12 hours. Daily doses, up to 300 mg / kg, are used without complications in young children and children with severe infections, including bacterial meningitis.
Intramuscular injection
For the preparation of solutions for intramuscular administration, the following solvents can be used:
-styrene water for injections;
-0.9% solution of sodium chloride;
-0.5% solution of lidocaine hydrochloride,
which are added to 1000 mg of cefoperazone in a volume of 3 ml. With intramuscular injection, the drug is injected deep into the gluteus muscle Freshly prepared solutions of cefoperazone are stored for no longer than 24 hours at a temperature of 5 to 25 ° C.
Intravenous administration.
With direct (jet) intravenous injection, the maximum single dose of cefoperazone for adults is 2000 mg, for children 50 mg / kg of body weight, while the duration of administration should be at least 3-5 minutes. A solution for intravenous administration is prepared ex tempore. The following solvents can be used:
dextrose 5%;
-0.9% solution of sodium chloride;
Ringer's lactate solution;
-styrene water for injections.
For intravenous administration of 1000 mg of cefoperazone is dissolved in 5 ml of sterile water for injection, the resulting solution is added to the infusion solution to a concentration of 20-100 mg / ml. The duration of administration, depending on the volume of the solution, can be 10 to 30 minutes or more.