Children the drug should be prescribed in daily doses at a rate of 50 to 200 mg per 1 kg of body weight; the drug should be injected every 8-12 hours. The maximum daily dose is 12 g.
With intravenous infusion of slow injection, the maximum single dose is 50 mg / kg of body weight; duration of administration - at least 3-5 minutes.
Newborns (Less than 8 days) the daily dose is from 50 to 200 mg / kg; the drug should be injected every 12 hours.
When abnormal liver function Dose adjustment may be required when severe severe obstruction of the bile duct, or severe liver disease with concomitant renal dysfunction. The daily dose should not exceed 2 g, with no need to control the concentration of cefoperazone in serum.
Patients with impaired renal function the drug can be administered in an average daily dose (2-4 g). Patients who have glomerular filtration rate below 18 ml / min, or serum creatinine above 3.5 mg / dL, the daily dose should not exceed 4 g In hemodialysis cefoperazone half-life from the blood serum decreases somewhat, and the drug should be administered after dialysis closure.
Rules for the preparation and administration of a solution for intravenous administration
For the preparation of solutions intended for w / o Injection, may be used sterile water for injection or 0.9% solution of sodium chloride. For breeding 1 g - 4 ml to obtain a final concentration of cefoperazone 250 mg / ml.To reduce pain with intramuscular injections, when a solution with a concentration of 250 mg / ml and more is intended to be administered, it is recommended to use a 2% lidocaine solution to prepare the solution (in case the patient has no hypersensitivity reaction to lidocaine). This solution can be prepared using sterile water for injection in combination with a 2% solution of lidocaine. The following two-step method of dilution is recommended: first add the required amount of sterile water for injection and shake until the powder cefoperazona completely dissolved, then add the necessary amount of 2% lidocaine and mix.
| | The final concentration of cefoperazone | Stage 1 Sterile water volume | 2 stage Volume of 2% lidocaine |
| Bottle 1 g | 250 mg / ml | 2.6 ml | 0.9 ml |
| Bottle 1 g | 333 mg / ml | 1.8 ml | 0.6 ml |
In / m injection is made deep into the large muscle (the gluteus maximus muscle or the anterior surface of the thigh).
Rules for the preparation and administration of a solution for intravenous administration Solution for intravenous administration is prepared ex tempore.
As a solvent, 5% dextrose solution, 10% dextrose solution, 0.9% sodium chloride solution, sterile water for injection can be used.
For cooking; solution for iv injection is necessary 1 g of cefoperazone dissolved in 10 ml of sterile water for injection or other compatible solution and injected for a minimum of 3-5 minutes. For intravenous administration, the maximum single dose of cefoperazone for adults is 2 g, for children - 50 mg / kg body weight.
When preparing a solution for intravenous administration of droplets to facilitate dissolution, it is recommended to use 5 ml of solvent per g of cefoperazone. The resulting solution is added to the infusion solution (Ringer's lactate solution, 5% dextrose solution, 0.9% solution of sodium chloride) in a volume of 20-100 ml. The duration of administration, depending on the volume of the solution can be from 10-30 minutes or more.