In / m and / in (slowly streaming or drip).
The drug is injected deep in the / m into the large gluteus muscle or the anterior surface of the thigh.
For IV injection, the maximum single dose is 2 g; duration of administration - at least 3-5 minutes. Duration iv in the drip introduction is 15-60 min.
The dose for adults is 2-4 g / day, divided into 2 injections (every 12 hours). In severe infections, the dose can be increased to 8 g / day, divided into 2 injections (every 12 hours). Complications when used in a daily dose of 12-16 g, divided into 3 injections, was not detected. Treatment with the drug can begin before the results of a study of the sensitivity of microorganisms.
With uncomplicated gonococcal urethritis - once in / m in a dose of 500 mg. Prevention of postoperative complications: 1 g or 2 g IV for 30-90 minutes before the operation, followed by repeated administration every 12 hours (in most cases within 24 hours).In operations with an increased risk of infection (for example, operations in the colorectal area), in open-heart surgery or joint replacement, prophylactic use can continue for 72 hours after the operation is completed.
Dose adjustments may be required in cases of severe obstructed bile duct obstruction, severe liver disease, or concomitant liver and kidney dysfunction. In this case, the daily dose should not exceed 2 g, while there is no need to monitor serum concentrations.
Because the
cefoperazone is mainly excreted not through the kidneys, then dose adjustments for renal dysfunction when administered at recommended doses (2-4 g / day) are not required. Patients who have a glomerular filtration rate below 18 ml / min, or a serum creatinine concentration greater than 3.5 mg / dl, a daily dose should not exceed 4 g. With hemodialysis T1 / 2, cefoperazone from serum slightly decreases, so the drug should enter after the end of the dialysis session.
It is recommended to monitor the concentration of cefoperazone in the blood serum (assuming that the daily dose is more than 2 g) with a combined disturbance of liver and kidney function and, if necessary, adjust the dose.
The dose for children is 50-200 mg / kg / day, divided into equal parts, administered every 8-12 hours. The maximum dose is 12 g / day. With IV slow injection, the maximum single dose is 50 mg / kg; duration of administration - at least 3-5 minutes. Newborns (aged less than 8 days) - 50-200 mg / kg / day in equal parts every 12 hours.
In the treatment of infections caused by Streptococcus pyogenes in adults and children, the duration of therapy should be at least 10 days. To prepare solutions for intramuscular injection, sterile
water for injection, 0.9% solution of sodium chloride (to 1 g of cefoperazone add 3 ml of solvent).
In cases where the solution is supposed to be in a concentration that exceeds 250 mg / ml, 0.5% lidocaine solution is recommended for solution preparation. Such a solution can be prepared using sterile water for injection and 2% (20 mg / ml) lidocaine solution, the final lidocaine concentration should be 0.5%. It is recommended to use a two-stage dissolution method: first, add the necessary amount of sterile water for injection, shake until the powder is completely dissolved, and then add the required amount of 2% lidocaine solution (see table):
| The content of cefoperazone in the vial, g | The final concentration of the solution of cefoperazone in the vial, mg / ml | Volume of sterile water, ml | Volume of 2% lidocaine solution, ml | The volume of the final solution taken for administration |
| 0,5 | 250 | 1,3 | 0,45 | 2,0 |
| 0,5 | 333 | 0,9 | 0,3 | 1,5 |
| 1 | 250 | 2,6 | 0,9 | 4,0 |
| 1 | 333 | 1,8 | 0,6 | 3,0 |
| 2 | 250 | 5,2 | 1,8 | 8,0 |
| 2 | 333 | 3,7 | 1,2 | 6,0 |
For the preparation of solutions for intravenous administration, the following solvents can be used:
- 0.9% solution of sodium chloride;
- sterile
water for injections.
For intravenous drip, the drug is dissolved at a rate of 5 ml of sterile
water for injection per 1 g of cefoperazone, the resulting solution is added to the appropriate solution for intravenous administration to a concentration of 20-100 mg / ml. When used as a solvent for sterile water for injection, its volume should not exceed 20 ml.
With intravenous slow jet injection, the drug is dissolved in a suitable solvent with a final concentration of 100 mg / ml and injected slowly for at least 3-5 minutes.