The dose of the drug is selected individually, depending on the age, severity of symptoms and composition of the diet. The dose is selected with the help of registered medicines Mikrazim® 10000 ED and Mikrazim® 25000 ED.Capsules are taken orally, squeezed with a sufficient amount of non-alkaline liquid (water, fruit juices). If a single dose of the drug is more than 1 capsule, you should take half of the total number of capsules immediately before eating, and the other half - while eating. If a single dose is 1 capsule, it should be taken with meals. If swallowing is difficult (for example, in children or the elderly), the capsule can be opened and taken directly into microgranules, mixed with liquid or liquid food (pH <5.0), not requiring chewing (apple puree, yogurt). Grinding or chewing pellets, as well as adding them to food with a pH above 5.5, leads to the destruction of their shell, which protects against the action of gastric juice. Any mixture of microgranules with food or liquid should be taken immediately after preparation.,
The admissible dose for children under the age of 13 years is 50000 U / day; over 1,5 years - 100 000 units / day.
The duration of pancreatin can vary from several days (digestive disorders) to several months or years (prolonged replacement therapy).
Replacement therapy for various types of exocrine pancreatic insufficiency.
The dose is selected individually and depends on the degree of manifestation of exocrine insufficiency, individual eating habits and the patient's age.
Steatorrhea (more than 15 grams of fat in the feces per day).
In the presence of diarrhea, a decrease in body weight and no effect of dietary therapy, 25,000 units of lipase are administered at each meal. If necessary and good tolerability dose increase to 30 000 - 35 000 units of lipase per dose. A further increase in the dose, in most cases, does not improve the results of treatment and requires a revision of the diagnosis, a decrease in the fat content in the diet, and / or an additional prescription of proton pump inhibitors.
With a mildly expressed steatorrhea, not accompanied by diarrhea and a decrease in body weight, a dose of 10,000 units to 25,000 units of lipase is administered.
Cystic fibrosis.
The initial calculated dose for children under 4 years is 1,000 ED lipase per kilogram of body weight for each feeding, for children older than 4 years, 500 ED of lipase per kilogram of body weight at each meal. The dose should be selected individually, depending on the severity of the disease, the severity of steatorrhea and nutritional status. The maintenance dose for most patients should not exceed 10,000 units of lipase per kilogram of body weight per day.