Mikrazim® can be administered to patients of all ages, including infants and elderly people, thanks to the possibility of individual dose selection by combining drugs with different dosages, and also because of the possibility of using directly the contents of gelatin capsules (microgranules).
Capsules are taken orally, during or after a meal, without chewing, squeezed with enough liquid (water, juices). If a single dose of the drug is more than 1 capsule, you should take half of the total number of capsules immediately before eating, and the other half - while eating. If a single dose is 1 capsule, it should be taken with meals.
If swallowing is difficult (for example, in young children or elderly people), the capsule is opened and taken directly in microgranules, mixed with a slightly acidic (pH <5.0) liquid or liquid in consistency with food that does not require chewing (pH <5,0 ). Any mixture of microgranules with food or liquid should be taken immediately after preparation.
When treating Mikrazim® to prevent constipation, it is important to ensure a normal level of water intake, especially with increased loss of fluid.
The dose of the drug is selected individually depending on the age and severity of the symptoms. To achieve adekvatnoy individual dose, except for capsules Mikrazim® 40000ED, It is possible to use the drug Mikrazim® with a dosage of 10000 units or 25000ED.
Cystic fibrosis.
For children older than 4 years, the average dose is 500 units lipases on kiThe body weight at each meal. For children under 4 years of age, the initial calculated dose of 1000 units of ED lipase per kilogram of body weight for each feeding (it is recommended to use the drug Mikrazim® 10000 U or 25,000 units)
The dose should be selected individually, depending on the severity of the disease, the severity of steatorrhea and nutritional status. The maintenance dose for most patients should not exceed 10,000 units of lipase per kilogram of body weight per day.,
In other conditions, accompanied by exocrine pancreatic insufficiency, the dose is set individually, taking into account the degree of insufficiency of digestion and the content of fats in food, individual eating habits and the age of the patient: The dose of lipase required by the patient during the main meal (breakfast, lunch or dinner) varies from 20,000 units to 75,000 units,
When treated with Mikrazim®, the average initial dose of lipase is 10,000-25,000 units at the time of the main meal (with the use of Mikrazim 10000 ED or Mikrazim 25,000 units), but higher doses may be required to achieve a therapeutic effect. Usually the patient should receive, together with food, at least 20,000 ED-50,000 units of lipase
With severe steatorrhea (more than 15 grams of fat in the feces per day), in the presence of diarrhea, a decrease in body weight and no effect of diet therapy, treatment starts with a dosage of 25,000 units of lipase at each meal, but if necessary and good tolerability, the dose is increased to 35,000 units -40000 units of lipase per dose. Further increasedose in most cases does not improve the results of treatment and requires a revision of the diagnosisbehind, reduction of fat in the diet and / or additional prescription of drugs - proton pump inhibitors.
The average dose of pancreatin for adults is 150000 U / day; with a complete blockade of the exocrine function of the pancreas - 400,000 units / day, which corresponds to the daily needs of an adult in lipase. The maximum daily dose is 15,000 ED-20000 units / kg. The admissible dose for children under the age of 1.5 years is 50000 U / day; over 1,5 years - 100,000 units / day. The duration of pancreatin can vary from several days (digestive disorders) to several months or years (prolonged replacement therapy).