Penzital - instructions for use, dose, side effects, contraindications

Excipients: lactose, microcrystalline cellulose, sodium starch glycolate, povidone, talc, silicon dioxide colloid, methacrylic acid copolymer, diethyl phthalate, titanium dioxide.

Description:White, round, biconvex tablets, covered with a film membrane.

Pharmacotherapeutic group:digestive enzyme.

ATX: & nbsp

A.09.A.A Enzyme preparations

A.09.A.A.02 Pancreatin

Pharmacodynamics:

Compensates the insufficiency of the exocrine function of the pancreas, has a proteolytic, amylolytic and lipolytic effect.

The enzymes included in the pancreatin (lipase, alpha-amylase, trypsin, chymotrypsin) promote the breakdown of proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides. Improves the functional state of the gastrointestinal tract, normalizes the digestive process.

Trypsin inhibits stimulated secretion of the pancreas, providing analgesic effect.

Pancreatic enzymes are released from the dosage form in the alkaline environment of the small intestine, since they are protected from the action of gastric juice by the membrane.

The maximum enzymatic activity is observed 30-45 minutes after oral administration.

Indications:

Substitution therapy with exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, Remkheld syndrome (gastrocardial syndrome), cystic fibrosis; flatulence, diarrhea of non-infectious genesis.

Disturbance of the assimilation of food (state after resection of the stomach and small intestine); to improve the digestion of food in individuals with normal gastrointestinal function in the event of errors in nutrition (eating fatty foods, large amounts of food,irregular feeding) and with violations of masticatory function, sedentary lifestyle, prolonged immobilization. Preparation for X-ray examination and ultrasound of the abdominal cavity organs.

Contraindications:

Hypersensitivity to the components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis.

Dosing and Administration:

Inside. The drug is taken during or after meals, without chewing and washing with non-alkaline liquid (water, fruit juices).

The dose is determined individually depending on the degree of digestion disorders. Adults usually - 1 - 2 tablets 3 times a day.

In children, the drug is used as directed by a doctor.

The duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in the diet) to several months or years (if necessary, permanent replacement therapy).

Side effects:

Allergic reactions. In some cases - diarrhea, constipation, a feeling of discomfort in the stomach, nausea (the cause-and-effect relationship of the development of these reactions with the action of pancreatin is not established, tk.these phenomena refer to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, it is possible to develop hyperuricosuria, an increase in the level of uric acid in the blood plasma. In case of cystic fibrosis in case of exceeding the necessary dose of pancreatin, development of strictures (fibrous colonopathy) in the ileocecal region in the ascending colon can be possible.

When using pancreatin in high doses, children may experience perianal irritation and irritation of the mucous membrane of the oral cavity.

Overdose:

Symptoms: hyperuricosuria, hyperuricemia. Children have constipation.

Treatment: withdrawal of the drug, symptomatic therapy.

Interaction:

With the simultaneous use of pancreatin with iron preparations, it is possible to reduce absorption of the latter. The simultaneous use of antacid agents containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of pancreatin.

Special instructions:

The safety of pancreatin in pregnancy is not well understood. The application is possible in cases where the expected benefit for the mother exceeds the potential risk to the fetus.

Cystic fibrosis does not recommend the use of pancreatin in high doses due to an increased risk of stricture (fibrous colonopathy). The dose should be adequate to the number of enzymes that are necessary for the absorption of fats, taking into account the quality and quantity consumed food.

With prolonged use, iron preparations are simultaneously prescribed.

Form release / dosage:Tablets, covered with enteric coating.

Packaging:

For 10 tablets coated with enteric coating in strips. 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12 strips in a cardboard box together with instructions for use.

Storage conditions:At temperatures from + 2 ° to + 25 ° C, in a dry place inaccessible to children.

Shelf life:3 years. Do not use after the expiration date stated on the package.

Terms of leave from pharmacies:Without recipe

Registration number:П N014636 / 01

Date of registration:23.01.2009

The owner of the registration certificate:Shraya Life Senses Pvt. Ltd.Shraya Life Senses Pvt. Ltd. India

Manufacturer: & nbsp

SHREYA LIFE SCIENCES, Pvt.Ltd. India

Representation: & nbspSHREYA LIFE SENENSIZ Pvt.Ltd. SHREYA LIFE SENENSIZ Pvt.Ltd. India

Information update date: & nbsp19.08.2015

Illustrated instructions

Instructions

Penzital (Penzital)