Pancreatin - instructions for use, dose, side effects, contraindications

Auxiliary substances: sugar milk (lactose), gelatin, potato krazmal, calcium stearate, cellase (acetyl phthalate cellulose), titanium dioxide (titanium dioxide), paraffin liquid (vaseline oil), tween-80 (polysorbate), dye azorubin (acid red 2C) .

Description:The tablets covered with a cover of pink or dark pink color, with a specific smell, biconcave form. Two layers are visible on the cross-section, inclusions are allowed in the inner layer.

Pharmacotherapeutic group:digestive enzyme.

ATX: & nbsp

A.09.A.A Enzyme preparations

A.09.A.A.02 Pancreatin

Pharmacodynamics:

Compensates for the deficiency of the external secretory function of the pancreas, has a proteolytic, amylolytic and lipolytic effect.

The enzymes included in the pancreatin (lipase, amylase, trypsin, chymotrypsin) promote the breakdown of proteins to amino acids, fats to glycerol and fatty acids, starch to dextrins and monosaccharides.

Improves the functional state of the gastrointestinal tract, normalizes the digestive process.

Trypsin inhibits the stimulated secretion of the pancreas, providing analgesic effect.

Pancreatic enzymes are released from the dosage form in the alkaline medium of the small intestine. protected from the action of gastric juice shell.

Indications:

Substitution therapy with exocrine pancreatic insufficiency: chronic pancreatitis, pancreatectomy, condition after irradiation, dyspepsia, cystic fibrosis.

Flatulence, diarrhea of non-infectious genesis, Remkheld's syndrome (gastrocardial syndrome).

Disturbance of the assimilation of food (state after resection of the stomach and small intestine); to improve the digestion of food in individuals with normal function of the gastrointestinal tract in the event of errors in nutrition (eating fatty foods, large amounts of food, irregular meals) and in cases of malfunctioning, sedentary lifestyle, long-term immobilization.

Preparation for X-ray and ultrasound examination of the abdominal cavity.

Contraindications:

Hypersensitivity to the components of the drug, acute pancreatitis, exacerbation of chronic pancreatitis, children under 6 years.

Pregnancy and lactation:

The safety of pancreatin in pregnancy is not well understood. The application is possible in cases where the expected benefit for the mother exceeds the potential risk to the fetus. During the lactation period, the use of pancreatin is not contraindicated.

Dosing and Administration:

Inside. The drug is taken during or after meals, without chewing and washing with non-alkaline liquid (water, fruit juices).

The dose is determined individually depending on the degree of digestion disorders.

Adults usually have 2 to 4 tablets 3 to 6 times a day. The maximum daily dose is 16 tablets.

In children older than 6 years, the drug is used as directed by a doctor. The dose is determined individually. Usually appoint 1 tablet 3 times a day.

Duration of treatment can vary from several days (if the digestive process is disturbed due to inaccuracies in the diet) toseveral months or years (if necessary, permanent replacement therapy).

Side effects:

Allergic reactions. Rarely - diarrhea, constipation, a feeling of discomfort in the stomach, nausea (the cause-and-effect relationship of the development of these reactions with the action of pancreatin is not established, because these phenomena refer to symptoms of exocrine pancreatic insufficiency). With prolonged use in high doses, it is possible to develop hyperuricosuria, hyperuricemia. In case of cystic fibrosis in case of excess of the necessary dose of Pancreatin, development of strictures (fibrous colonopathy) in the ileocecal region in the ascending colon can be possible.

When using pancreatin in high doses, children may experience perianal irritation and irritation of the mucous membrane of the oral cavity.

Overdose:Symptoms: hyperuricosuria, hyperuricemia. Children have constipation.

Treatment: withdrawal of the drug, symptomatic therapy.

Interaction:

When using pancreatin, it is possible to reduce the absorption of iron and folic acid. The simultaneous use of antacid agents containing calcium carbonate and / or magnesium hydroxide, can lead to a decrease in the effectiveness of pancreatin.

Special instructions:

Cystic fibrosis does not recommend the use of pancreatin in high doses due to an increased risk of stricture (fibrous colonopathy).

The dose should be adequate to the number of enzymes that are needed to absorb fat, taking into account the quality and quantity of food consumed.

Form release / dosage:Tablets, coated with enteric coating, 25 units.

Packaging:

For 60 tablets in cans of orange glass with pull-on lids or in polymer cans.

For 10 tablets in a contour mesh box made of polyvinylchloride film and aluminum foil or paper with polyethylene coating.

Each jar or 2, 3, 6 contour squares, together with instructions for the use of the drug, are placed in a pack of cardboard.

It is allowed to have 50 cans and 100 contour packs with the application of an equal number of instructions for use in boxes (with partitions for cans) made of cardboard.

Storage conditions:

In a dry place inaccessible to children, at a temperature not exceeding 20 ° C.

Shelf life:

2 years. Do not use after the expiration date

Terms of leave from pharmacies:Without recipe

Registration number:LSR-001342/08

Date of registration:29.02.2008

The owner of the registration certificate:BIOSINTEZ, PAO BIOSINTEZ, PAO Russia

Manufacturer: & nbsp

BIOSINTEZ, PAO Russia

Information update date: & nbsp21.08.2015

Illustrated instructions

Instructions

Pancreatin (Pancreatin)