Nicotinic acid - SOLOfarm - instructions for use, dose, side effects, contraindications

Nicotinic acid - a water-soluble vitamin of the B group replenishes the vitamin PP deficiency (vitamin B₃), is a specific antipelagic agent (Vitamin PP vitamin deficiency). Has vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, activates the fibrinolysis system. Has antiatherogenic properties.

Pharmacokinetics:

With parenteral administration, it is quickly distributed in the tissues of the body. It accumulates mainly in the liver, as well as in adipose tissue and in the kidneys. In the liver a nicotinic acid is converted into an amine that is inserted into the nicotinamide adenine dinucleotide (NAD), which is a progenitor group of enzymes that carry hydrogen and carry out oxidation-reduction processes.

The main metabolites are H-methyl-2-pyridone-3-carboxamide and Nmethyl-2-pyridone-5-carboxamide, which do not possess pharmacological activity. It can be synthesized in the intestine by a bacterial flora from the tryptophan that came with food (60 mg of tryptophan produces 1 mg of nicotinic acid) with the participation of pyridoxine (vitamin B₆) and riboflavin (vitamin B₂).

The elimination half-life is 45 minutes.

It is excreted from the body by the kidneys in unmodified form and in the form of metabolites, when taking high doses - mostly unchanged. Kidney clearance depends on the level of nicotinic acid in the blood plasma and can decrease with a high concentration of it in the plasma.

Indications:

- Avitaminosis PP (pellagra).

- Complex therapy: ischemic stroke; obliterating diseases of the vessels of the extremities (obliterating endarteritis, Raynaud's disease); neuritis of the facial nerve.

- Hartnup disease (hereditary disease, accompanied by a violation of the assimilation of certain amino acids, including tryptophan).

Contraindications:

Hypersensitivity to the components of the drug, severe arterial hypertension, atherosclerosis, gout, hyperuricemia, hepatitis, decompensated diabetes, stomach and duodenal ulcer (at the stage of exacerbation), children's age (under 18 years).

Carefully:

Hemorrhage, glaucoma, hepatic insufficiency, arterial hypotension, hyperacid gastritis, peptic ulcer of the stomach and duodenum (outside stages of exacerbation).

Pregnancy and lactation:

Taking into account the injection route of the drug, its side effects, the use during pregnancy strictly according to the doctor's prescription, if the expected effect of therapy for the mother exceeds the potential risk to the fetus.

If you need to use the drug during lactation, breastfeeding should be discontinued.

Dosing and Administration:

The drug is used subcutaneously, intramuscularly, intravenously (slowly).

With pellagra (vitamin avitaminosis PP), 1 ml of 1% (10 mg) solution is administered parenterally 1-2 times a day for 10-15 days.

With ischemic stroke 10 mg of solution is slowly injected intravenously.

With Hartnup's disease: 40-200 mg per day.

With other indications, indicated in the section "Indications for use" - 10 mg 1-2 times a day, for 10-15 days.

Maximum doses for adults: single dose - 100 mg, daily - 300 mg.

Side effects:

From the side of the cardiovascular system: a sensation of "tidal" blood to the scalp,hyperemia of the facial skin and upper half of the trunk with a sensation of tingling and burning, with rapid administration - lowering of arterial pressure, orthostatic hypotension, collapse.

From the central nervous system and the peripheral nervous system: paresthesia, dizziness.

From the digestive system: with prolonged use - fatty degeneration of the liver.

From the side of metabolism: with long-term use - hyperuricemia, a decrease in glucose tolerance, an increase in blood levels of aspartate aminotransferase, lactate dehydrogenase, alkaline phosphatase.

Local Reactions: pain in the place of subcutaneous and intramuscular injection.

Other: allergic reactions (skin rash, itchy skin, breathy breath).

Overdose:

Overdose is unlikely because of the low toxicity of the drug. A nicotinic acid in individuals with intolerance can cause reddening of the face and upper body, dizziness, headache, hives, paresthesia (numbness, loss of sensation, tingling, crawling).

Treatment: symptomatic.

Interaction:

Care should be taken when combining with antihypertensives, anticoagulants and acetylsalicylic acid.

Nicotinic acid reduces the toxicity of neomycin and prevents the decrease in the concentration of high-density cholesterol and lipoproteins induced by it.

When combined with the drugs, sulfonylureas can increase the glucose level in the blood.

When administered with lovastatin increases the risk of myopathy.

Special instructions:

During the treatment, liver function should be monitored regularly. With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration. To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) or methionine or other lipotropic agents in the diet.

Effect on the ability to drive transp. cf. and fur:

During the period of treatment it is recommended to refrain from driving vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Solution for injection, 10 mg / ml.

Packaging:

1 ml per ampoule of colorless or colored glass.

By 5 or 10 ampoules in a contiguous cell pack of a polyvinylchloride film and a polymer film, or without a polymer film, or in the form of a cardboard with cells for laying ampoules.

On 1 contour acheikova packing or the form from a cardboard with 10 ampoules or 2 contour cellular packings or forms from a cardboard with 5 ampoules together with instructions for use and scarifier ampoules or ampoules without a scarifier in a pack of cardboard.

Storage conditions:

Store at a temperature not exceeding 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years.

Do not use after the expiration date.

Terms of leave from pharmacies:On prescription

Registration number:LP-003839

Date of registration:14.09.2016

Expiration Date:14.09.2021

The owner of the registration certificate:GROTEKS, LLC GROTEKS, LLC Russia

Manufacturer: & nbsp

GROTEKS, LLC Russia

Representation: & nbspGROTEKS, LLCGROTEKS, LLC

Information update date: & nbsp30.09.2016

Illustrated instructions

Instructions

Nicotinic acid - SOLOfarm (Nicotinic acid - SOLOfarm)