Nicotinic acid - instructions for use, dose, side effects, contraindications

Vitamin product. A nicotinic acid and amidnicotinic acid are closely related to the coenzymes of codohydrase I and codehydrogenase II (NAD and NADP) carrying hydrogen, participating inin metabolism, tissue respiration; synthetic processes. Replenishes the deficittammin PP, is a specific antipellagic agent (vitamin PP). Has a vasodilating effect on the level, small vessels (including the head brain), improves microcirculation, has a weak anticoagulant effect (increases fibrinolytic activity of blood), has detoxification properties.

Pharmacokinetics:

In the body it is transformed into nicotinamide. Accumulates in the liver, and in adipose tissue and in the kidneys. Metabolised in the liver. The main metabolites are N-methyl-2-pyridone-3-carboxamide and N-methyl-2-pyridone-5-carboxamide. do not have pharmacological activity.

It is excreted by the kidneys in the form of metabolites, when taking high doses - mostly unchanged.

Indications:

Pellagra (avitaminosis PP), ischemic disorders of cerebral circulation, neuritis of the facial nerve, alcohol intoxication.

Contraindications:

Hypersensitivity to the drug components, arterial hypertension (severe forms) and atherosclerosis (for intravenous administration), gastric and duodenal ulcer (at the stage of exacerbation), gout, hyperuricemia, urate nephrolithiasis, cirrhosis, uncompensated diabetes mellitus, pregnancy, period lactation, children's age.

Carefully:Hyperacid gastritis, peptic ulcer of stomach and duodenum (beyond stage exacerbation), bleeding, glaucoma, liver failure; arterial hypotension.

Dosing and Administration:

Assign adults subcutaneously, intramuscularly and intravenously (slowly) 1-2 times a day, for 10-15 days.

At a pellagraum appoint or nominate on 10 mg (1 ml of 1% of a solution). With ischemic disorders of cerebral circulation, intravenously 10-50 mg (1-5 ml of 1% solution) is prescribed.

With alcohol intoxication appoint subcutaneously or intramuscularly 1-2 ml.

When neuritis of the facial nerve appoint 10-20 mg (1-2 ml of 1% solution) intramuscularly.

Side effects:

Allergic reactions, hyperemia of the skin of the face and upper half of the trunk with sensations tingling and burning, paresthesia, dizziness, "tides" of blood to the skin of the face, with rapid introduction - lowering of arterial pressure, orthostatic hypotension, collapse. With prolonged use - fatty liver disease; hyperuricemia, decrease tolerance to glucose, elevated blood levels ACT, LDG, APF. Soreness in places of subcutaneous and intramuscular injection.

Overdose:

Symptoms: increased side effects - arterial hypotension, dizziness, a sense of blood rush to the head.

Treatment: withdrawal of the drug, symptomatic therapy. There is no specific antidote.

Interaction:

Care should be taken when combining with antihypertensives, anticoagulants and acetylsalicylic acid. Reduces the toxicity of neomycin and prevents its induced decrease in the concentration of high density cholesterol and lipoproteins (HDL).

Special instructions:

During the treatment it is necessary to monitor the function of the liver.

It is inappropriate to use for correction of dyslipidemia in patients with diabetes mellitus.

To prevent complications from the liver it is recommended to include in the diet products rich in methionine (cottage cheese), or use methionine, lipoic acid and other lipotropic drugs.

Effect on the ability to drive transp. cf. and fur:During the treatment period, one should refrain from managing motor vehicles and practicing potentially dangerous activities that require an increased concentration of attention and speed: psychomotor reactions.

Form release / dosage:

Solution for injection, 10 mg / ml, in ampoules of 1 ml.

5 ampoules per blister of a polyvinyl chloride film. 2 blisters together with the instruction 'for medical use, with a ceramic disc or ampoule ceramic knife in a pack of cardboard ..

For 10 ampoules, along with instructions for medical use, a cutting disc, ceramic or knife ampoule ceramic in a pack with partitions of cardboard.

It is allowed when packing the drug in ampoules with a ring of fracture, a ceramic cutting disc or an ampoule ceramic knife is not to be put.

Packaging:ampoules (10) / complete with a ceramic or knife disc ampoule, if necessary for ampoules of this type / - packs cardboard
ampoules (5) / complete with ceramic disc or knife ampoule, if necessary for ampoules of this type / - blister packs cardboard

Storage conditions:In the dark place at a temperature of 8 ° C to 25 ° C. Keep out of the reach of children.

Shelf life:Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N015076 / 01-2003

Date of registration:10.06.2008

The owner of the registration certificate:HEALTH PHARMACEUTICAL COMPANY, LTD. HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine

Manufacturer: & nbsp

HEALTH PHARMACEUTICAL COMPANY, LTD. Ukraine

Information update date: & nbsp13.08.2015

Illustrated instructions

Instructions

A nicotinic acid (Nicotinic acid)