Nicotinic acid - instructions for use, dose, side effects, contraindications

Nicotinic acid - a water-soluble vitamin B, replenishes vitamin PP deficiency (Vitamin B6), is a specific antipslargic agent (Vitamin PP vitamin avitaminosis). Has vasodilating effect on the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, activates the system of fibrinolysis. Has antiatherogenic properties.

Pharmacokinetics:

In the blood comes very quickly (for 20-30 minutes) after parenteral administration. In the blood, almost everything is connected with erythrocytes, in which it is converted into active co-enzymes: nicotypic dideucleotide (NAD) and nicotipamide dicleotide phosphate (NADP). NAD and NADO are found in all tissues of the body. Especially rich are the liver, muscles, kidneys, heart. In the body it is transformed into nicotinamide. Partially biogransformed in the liver with the formation of the main metabolites: M-methyl-2-pyridone-3-carboxamide and Nmethyl-2-pyridone-5-carboxamide. Metabolites do not have pharmacological activity. It is excreted by the kidneys in the form of metabolites, when taking high doses - mostly unchanged.

Indications:

- Avitaminosis PP(pellagra).

- Complex therapy:

ischemic stroke; obliterating diseases of the vessels of the extremities (obliterating endarteritis, Raynaud's disease); neuritis of the facial nerve.

- Hartnup disease (hereditary disease, accompanied by a violation of the assimilation of certain amino acids, including tryptophan).

Contraindications:Hypersensitivity to the components of the drug, severe arterial hypertension, atherosclerosis, gout, hyperuricemia, hepatitis, uncompensated diabetes, stomach and duodenal ulcer (at the stage of exacerbation), children's age (under 18 years).

Carefully:hemorrhage, glaucoma, hepatic insufficiency, arterial hypotension, gynecidal gastritis, gastric ulcer and duodenal ulcer (outside the stage of exacerbation).

Pregnancy and lactation:

The drug is contraindicated in pregnancy and during breastfeeding.

Dosing and Administration:

The drug is used subcutaneously, intramuscularly, intravenously (slowly).

With pellagra (avitaminosis PP), 1 ml of 1% (10 mg) solution is administered parenterally 1-2 times a day for 10-15 days.

In ischemic stroke, I ml of 1% (10 mg) solution intravenously for 10-12 days.

With the remaining indications indicated in the section "Indications for use" - 10 mg 1-2 times a day, for 10-15 days.

Higher doses for adults: single 100 mg, daily - 300 mg.

Disease Hartnup 40 - 200 mg per day.

Side effects:

From the cardiovascular system: hyperemia of the facial skin and upper half of the trunk with a sensation of tingling and burning, with rapid administration - lowering of arterial pressure, orthostatic hypotension, collapse.

From the central nervous system and the peripheral nervous system: paresthesia, dizziness.

From the digestive system: with prolonged use - fatty degeneration of the liver.

From the side of metabolism: with long-term use - gipsrurixmia, a decrease in the glucose tolerance, an increase in the blood content of asparagines and notransferase, lac tatdehydrogenase, alkaline phosphatase.

Local reactions: pain in the place of subcutaneous and intramuscular injection. Other: allergic reactions (skin rash, skin itching, stridoroznos respiration).

Overdose:

Overdose is unlikely because of the low toxicity of the drug. A nicotinic acid in persons with individual intolerance can cause reddening of the face and upper half of the trunk, dizziness, a feeling of blood rush to the head, urticaria, paresthesia (sensation of numbness, loss of sensation, tingling, crawling). These phenomena pass by themselves and do not require special treatment.

Interaction:

Care should be taken when combining with antihypertensives, anticoagulants and acetylsalicylic acid.

Nicotinic acid reduces the toxicity of neomycin and prevents the decrease in the concentration of cholesterol and high-density lipoproteins induced by it.

When combined with the drugs, sulfoiylmachine can increase the glucose level in the blood. When administered with lovastatin increases the risk of developing mionatia.

Special instructions:During the treatment, liver function should be monitored regularly.With prolonged use of nicotinic acid in high doses, it is possible to develop fatty liver infiltration. To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) or methionine or other lipotropic agents in the diet.

Effect on the ability to drive transp. cf. and fur:During the period of treatment it is recommended to refrain from driving vehicles and practicing other potentially dangerous activities that require an increased concentration of attention and speed of psychomotor reactions.

Form release / dosage:

Solution for injection 10 mg / ml.

1 ml or 10 ml into neutral glass ampoules. For 10 ampoules, together with the instruction for use and the ampoule opening opener or ampoule scarifier, is placed in a cardboard box.

When using ampoules with notches, rings or break points, the ampoule opener opener or ampoule scarifier is allowed not to be inserted.

5 ampoules (for 1 ml ampoules) are placed in a contour mesh package. 2 contour mesh packages along with the instruction for use are placed in a pack of cardboard.

Packaging:(1) - ampoules (10) / complete with instructions for use, with a knife ampoule or scarifier, if necessary for ampoules of this type / - Cardboard box
(1) - ampoules (10) / complete with instructions for use, with a knife ampoule or scarifier, if necessary for ampoules of this type / - cardboard pack
(10) - ampoules (10) / complete with instructions for use, with a knife ampoule or scarifier, if necessary for ampoules of this type / - Cardboard box

Storage conditions:

In the dark place at a temperature of 5 to 25 ° C.

Keep out of the reach of children.

Shelf life:

5 years. Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:P N003843 / 01

Date of registration:16.10.2009

The owner of the registration certificate:DALHIMFARM, OJSC DALHIMFARM, OJSC Russia

Manufacturer: & nbsp

DALHIMFARM, OJSC Russia

Information update date: & nbsp11.08.2015

Illustrated instructions

Instructions

A nicotinic acid (Nicotinic acid)