Nicotinic acid - instructions for use, dose, side effects, contraindications

Composition: 1 ml of the solution contains the active substance: nicotinic acid - 10 mg, auxiliary substances: sodium bicarbonate - to pH 5.0-7.0; water for injection - up to 1 ml.

Description:clear colorless liquid.

Pharmacotherapeutic group:Vitamin

ATX: & nbsp

C.10.A.D. Nicotinic acid and its derivatives

C.10.A.D.02 A nicotinic acid

Pharmacodynamics:

Nicotinic acid - water-soluble vitamin B, replenishes vitamin PP deficiency (vitamin B3), is a specific antipellar agent (vitamin PP vitamin deficiency). The mechanism of its action is to suppress the mobilization of fatty acid synthesis from adipose tissue, to reduce the formation of very low density lipoproteins in the liver, to reduce the triglycerides in the blood. Along with this, it reduces the formation and content in the blood of low density lipoproteins and cholesterol. It has a vasodilating effect at the level of small vessels (including the brain), improves microcirculation, has a weak anticoagulant effect, activates the fibrinolysis system and increases the size of low density lipoproteins, which makes it difficult to infiltrate them into intima of the arteries, the level of high-density lipoprotein cholesterol levels, including in normolipidemia.

Pharmacokinetics:

In the blood comes very quickly (20-30 minutes) after parenteral administration.In the blood, almost everything is connected by red blood cells, in which it turns into active coenzymes: NAD (nicotinamide dinucleotide) and NADP (nicotinamide dinucleotide phosphate). NAD and NADP are found in all tissues of the body. Especially rich are the liver, muscles, kidneys, heart. In the body it is transformed into nicotinamide. Partially biotransformed in the liver to form the main metabolites: N-methyl-2-pyridone-3-carboxamide and - M-methyl-2-pyridone-5-carboxamide. Metabolites do not have pharmacological activity. It is excreted by the kidneys in the form of metabolites, when taking high doses - mostly unchanged.

Indications:

Avitaminosis PP: Ischemic disorders of cerebral circulation, obliterating diseases of the vessels of the extremities (obliterating endarteritis, Raynaud's disease), spasm of the vessels of the extremities, biliary and urinary tracts, neuritis of the facial nerve.

Contraindications:Hypersensitivity, severe arterial hypertension, atherosclerosis, gout, hyperuricemia, children's age. Intravenous injections are contraindicated in severe forms of hypertension (persistent increase in blood pressure) and arteriosclerosis.

Carefully:Hemorrhage, glaucoma, hepaticdeficiency, andmouthreal gipotency, hyperacid gastritis, peptic ulcer and 12-colon (at the stage of exacerbation). During the treatment, liver function should be monitored regularly. To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) or methionine or other lipotropic agents in the diet.

Pregnancy and lactation:Indication of the possibility and features of medical use of the drug by pregnant women and during breastfeeding The use of nicotinic acid solution during pregnancyand and dRmeaningful feeding is contraindicated.

Dosing and Administration:

Apply a solution of nicotinic acid subcutaneously, intramuscularly, intravenously (slowly). Subcutaneous and intramuscular injections are painful.

When pellagra (avitaminosis PP), 1% solution is administered parenterally 1 ml 1-2 times a day for 10-15 days.

With ischemic stroke, 1 ml of 1% solution is administered intravenously.

With other diseases apply 20-50 mg / day (up to 100 mg / day);

Higher doses for adults: single 100 mg, daily 300 mg.

Side effects:

From the cardiovascular system: hyperemia of the skin and upper half torso with a sensation of tingling and burning, with rapid administration - a decrease arterial pressure, orthostatic hypotension, collapse.

From the central nervous system and the peripheral nervous system: paresthesia, dizziness.

From the digestive system: with prolonged use - fatty liver.

From the side of metabolism: with long-term use - hyperuricemia, a decrease in glucose tolerance, an increase in the content of asparagine aminotransferase in the blood, lactate dehydrogenase, alkaline phosphatase.

Local reactions: pain in the place of subcutaneous and intramuscular injection.

Other: allergic reactions.

Overdose:

Overdose is unlikely because of the low toxicity of the drug. A nicotinic acid in persons with individual intolerance can cause redness of the face and upper half of the trunk, dizziness, a feeling of blood rush to the head, hives, parasthesia (sensation of numbness, loss of sensitivity, crawling, tingling). These phenomena pass by themselves and do not require special treatment.

Interaction:

It is necessary, to be careful when combining with antihypertensive drugs, anticoagulants and acetylsalicylic acid. A nicotinic acid reduces the toxicity of neomycin and prevents its induced decrease in the concentration of high-density cholesterol and lipoproteins.

Special instructions:

During the treatment, liver function should be monitored regularly. To prevent hepatotoxicity, it is necessary to include foods rich in methionine (cottage cheese) or methionine or other lipotropic agents in the diet.

Effect on the ability to drive transp. cf. and fur:Studies have not been conducted.

Form release / dosage:

Solution for injection 10 mg / ml. 1 ml into glass ampoules. For 10 ampoules together with a knife ampoule or scarifier ampoule and instructions for use in a cardboard box.

Packaging:(10) - neutral glass ampoule (10) / 10 ampoules, together with instructions for medical use, ampoule or ampoule knife with a knife in a cardboard box / - 10 ampoules in a cardboard box

Storage conditions:

Store in a protected from light at a temperature not exceeding 30 ⁰ FROM.

Keep out of the reach of children.

Shelf life:5 years.Do not use after the expiration date printed on the package.

Terms of leave from pharmacies:On prescription

Registration number:LS-002483

Date of registration:29.07.2011

The owner of the registration certificate:ORGANICS, JSC ORGANICS, JSC Russia

Manufacturer: & nbsp

ORGANICS, JSC Russia

Information update date: & nbsp10.08.2015

Illustrated instructions

Instructions

A nicotinic acid (Nicotinic acid)